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Details & care
What it is: A revolutionary wrinkle-fighting serum that helps skin appear noticeably younger.
What it does: It's packed with a 73% complex of 21 peptides and neuropeptides and two gamma proteins to target every area of the face and neck for 360° results, helping to visibly reduce the look of fine lines and wrinkles. The gamma proteins harness the power of Asian natto gum, a breakthrough ingredient that helps improve the look of elasticity, radiance, uneven skin tone and texture. It's also infused with squalane, a hyaluronic acid complex and vitamins A, C and E.
How to use: Apply twice daily after cleansing your face and neck.
- 1 oz.
- Made in the USA
- Item #5836934
Ingredients
Water/Aqua/Eau, Glycerin, Rosa Centifolia Flower Water, Isopropyl Myristate, Squalane, Mannitol, Butylene Glycol, Natto Gum, Tripeptide-10 Citrulline, Acetyl Octapeptide-3, Palmitoyl Hexapeptide-12, Acetyl Tetrapeptide-11, Acetyl Hexapeptide-8, Acetyl Hexapeptide-1, Palmitoyl Oligopeptide, Acetyl Tetrapeptide-9, Acetyl Tetrapeptide-2, Tripeptide-1, Palmitoyl Tetrapeptide-7, Hexapeptide-11, Dipeptide Diaminobutyroyl Benzylamide Diacetate, Palmitoyl Tripeptide-5, Trifluoroacetyl Tripeptide-2, Palmitoyl Tripeptide-1, Sodium Polyglutamate, Sodium Hyaluronate, Tocopheryl Acetate, Retinyl Palmitate, Ascorbic Acid, Hydrolyzed Soy Protein, Hydrolyzed Wheat Protein, Lecithin, Pseudoalteromonas Ferment Extract, Acrylates Copolymer, Magnesium Chloride, Polysorbate 20, Dimethyl Isosorbide, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Leuconostoc/Radish Root Ferment Filtrate, Peg-8 Dimethicone, Disodium Phosphate, Carbomer, Dextran, Sodium Lactate, Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate, Xanthan Gum, Triethanolamine, Sodium Phosphate, , Octyldodecanol, Silica, Sodium Propoxyhydroxypropyl Thiosulfate Silica, Sodium Hydroxide, Caprylyl Glycol, Potassium Sorbate, Sodium Benzoate, Phenoxyethanol.
Ingredients are subject to change at the manufacturer's discretion. For the most complete and up-to-date list of ingredients, refer to the product packaging
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Peter Thomas Roth
Launched in 1993, Peter Thomas Roth blends ancient Hungarian health and skin care philosophies with 21st-century technologies and ingredients. Founder Peter Thomas Roth's passion for skin care grew from his family's heritage as spa owners in Hungary, coupled with a personal quest to find solutions for his own skin problems. The result is breakthrough formulas that deliver astonishing results.
Most helpful positive review
Feb 17, 2026
Peptide Wrinkle Resist
[This review was collected as part of a promotion.] The peptide21 wrinkle resist is amazing. It goes on very well and absorbs quickly. I mainly target my crow’s feet and forehead and the spread over the rest of my face. I swear that I saw results the next day especially with my crow’s feet. This is such a wonderful product, and I will never be without it. I love it!
AnnaMae
Reposted from peterthomasroth.com
Most helpful critical review
Jan 13, 2025
21 wrinkle serum
I bought this, but when I went to use it, it has a floral smell to it. I can’t do any type of smells when it comes to make up.
Amys
Reposted from peterthomasroth.com
5 stars
75%
4 stars
5%
3 stars
7%
2 stars
7%
1 star
7%
Sort by Most Helpful
Ireneherbst
Sept 11, 2019
Incentivized review
Sticky and Thick
I was recommended this item from a member of our skincare FB group and so I had high hopes. I wanted something similar just like Shiseido Lift Serum but half the price. I tried PTR for a few days and I tried to like it but couldn’t. My face wasn’t as firm compared to using Shiseido, the serum was sticky, and a bit thick. The smell wasn’t pleasant at all as well. I really tried to like it but I guess it wasn’t for me. I ended up returning and now trying out SR CEO.
2found this helpful
AnnaMae
Reposted from peterthomasroth.com
Feb 17, 2026
Peptide Wrinkle Resist
[This review was collected as part of a promotion.] The peptide21 wrinkle resist is amazing. It goes on very well and absorbs quickly. I mainly target my crow’s feet and forehead and the spread over the rest of my face. I swear that I saw results the next day especially with my crow’s feet. This is such a wonderful product, and I will never be without it. I love it!
Mary1
Reposted from peterthomasroth.com
Feb 17, 2026
Best product I've ever tried
I am so sad that this product is being discontinued. Please make something similar in the future.
CCRA
Reposted from peterthomasroth.com
Aug 28, 2025
Youth in a bottle, I swear
I've been using this for years and I stopped recently for a couple months and my skin looked very aged even with using other peptides. As soon as I started using it again my skin is so revived and bright and I have noticeably less fine lines. Please don't even stop selling this!
katie z
Reposted from peterthomasroth.com
July 31, 2025
great ingredients great results
i am a huge fan of the peptide line have been using it consistently with good results! 5 stars for the product ingredients 3-4 stars due to the gritty texture that doesn't feel nice on your skin
Whitneyr
Reposted from peterthomasroth.com
Verified purchase
Apr 19, 2025
Ehhh
Very sticky! When you put it on your neck expect lint and whatever else off of your clothes to stick to it throughout the day! I also do not see any Improvement in wearing this, I'm very disappointed in this product!