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Details & care
What it is: A multitasking powerhouse that helps strengthen, soften and replenish the look of thin, crepey skin on your hands.
What it does: This silky cream intensely moisturizes skin and helps diminish the appearance of dark spots, veins and discoloration. It also helps tighten and brighten skin while smoothing the look of fine lines and wrinkles and improving skin's elasticity over time.
How to use: Apply liberally, massaging into your fingers and the backs of your hands. Use morning and evening and throughout the day as desired.
- 2 oz.
- Cruelty-free
- Made in the USA
- Item #5950599
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Perricone MD
Perricone MD founder Dr. Nicholas Perricone believes that true beauty comes from incredibly radiant health. The company's products use the most powerful ingredients on the planet, and are rooted in a holistic approach that is backed by science and research. Perricone MD never compromises on excellence and innovation because it's on a mission to revolutionize skin care for results you can see.
Most helpful positive review
Dec 10, 2025
Great Hand therapy
I've been using Cold Plasma Plus+ Hand Therapy for awile now. It does keep my hands soft, even using just a bit.
ReneeIlene
Verified purchase
Most helpful critical review
Apr 10, 2024
Small tube
Not much product for what you pay.
Annette
Verified purchase
5 stars
61%
4 stars
29%
3 stars
7%
2 stars
1%
1 star
2%
Pros:
Cons:
Sort by Most Helpful
danalu
Verified purchase
Feb 21, 2021
too soon to tell- bad packaging
Only been using two weeks so no results yet. Does go on smooth and not greasy. However, unless they change the bottle/ tube I will not buy again. It 's a soft tube with a plunger pump. I have stored it in all directions and it takes about 6-8 tries to get a small amount out of the tube. So bad I am thinking about cutting it open and placing contents in a jar.
2found this helpful
Abc23
Feb 11, 2021
Light hand cream
This cream is very light and absorbing. It doesn’t really have a smell which I prefer. I use this at night before bed. So far it’s ok.
2found this helpful
A fun Perricone user for
Reposted from Perricone MD
Verified purchase
Mar 4, 2026
Hands up !
Nothing shows the age of a woman if you look at their hands. This product does a nice job of making hands more opaque than the tissue paper skin over veins…..
Perricone MD response
Hello, we are delighted you liked this product and we thank you for sharing such a valuable feedback :)
ReneeIlene
Verified purchase
Dec 10, 2025
Great Hand therapy
I've been using Cold Plasma Plus+ Hand Therapy for awile now. It does keep my hands soft, even using just a bit.
Was this helpful?
Denise
Reposted from Perricone MD
Verified purchase
Dec 9, 2025
Nice
Very nice hand cream, keeps your hand soft. A bit pricey but I got these BOGO
Perricone MD response
It’s always a joy to hear from happy customers. We’re so glad we could deliver a great experience!
Susan
Reposted from Perricone MD
Verified purchase
Nov 9, 2025
Great hand cream
The best hand cream I have ever used! When I give it as a gift it is always a hit!
Perricone MD response
It’s always a joy to hear from happy customers. We’re so glad we could deliver a great experience!