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Perricone MD High Potency Intensive Smoothing Serum, Main, color,
Perricone MD High Potency Intensive Smoothing Serum, Alternate, color,
Perricone MD High Potency Intensive Smoothing Serum, Alternate, color,
Perricone MD High Potency Intensive Smoothing Serum, Alternate, color,
Perricone MD High Potency Intensive Smoothing Serum, Alternate, color,
Perricone MD High Potency Intensive Smoothing Serum, Alternate, color,

High Potency Intensive Smoothing Serum

Perricone MD

SOLD OUT

This item is no longer available. Browse our recommendations for something similar.

Details & care

What it is: A serum that features a high concentration of niacinamide to help minimize the look of imperfections, leaving skin soft and smooth.

Who it's for: Ideal for all skin types. Ideal for those dealing with loss of smoothness, fine lines and wrinkles, enlarged pores, uneven texture, crepiness and uneven tone.

What it does: The serum helps minimize the look of imperfections, including rough, uneven texture, enlarged pores and crepiness. It leaves skin feeling instantly soft. The fast-absorbing treatment glides on smoothly for a visibly refined complexion.

Key ingredients:

- Niacinamide: visibly renew and restores skin. Also known as vitamin B3, it helps minimize the look of imperfections, reduce uneven skin tone and diminish dullness by protecting the skin's moisture barrier. As a powerful antioxidant, it protects skin from oxidative stress and fights against free-radical damage.

DMAE: intensively firming. Naturally produced by the human brain, topical application of DMAE helps visibly tighten sagging skin over time. Easily and quickly absorbed, it helps visibly plump skin to support skin's surface and protect against drying environmental aggressors

- Ceramides: act as potent barrier support. An organic olive oil–derived complex delivers firmer, smoother-looking skin by intensely moisturizing, replenishing and protecting the skins moisture barrier. Ceramides represent close to 40% of our surface skin layer and help to protect against environmental aggressors

How to use: After cleansing, massage the serum onto face and neck using a gentle upward motion. Wait until fully absorbed and follow with your favorite Perricone MD moisturizer (sold separately). Use morning and evening.

  • 2 oz.
  • Made in the USA
  • Item #10350762

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Perricone MD

Perricone MD founder Dr. Nicholas Perricone believes that true beauty comes from incredibly radiant health. The company's products use the most powerful ingredients on the planet, and are rooted in a holistic approach that is backed by science and research. Perricone MD never compromises on excellence and innovation because it's on a mission to revolutionize skin care for results you can see.

Reviews

(962)
4.7 out of 5
Write a Review

Most helpful positive review

Feb 5, 2026
Smoothing serum
I’ve noticed a significant change in the texture of my skin, I’m obsessed!
Kelli
Verified purchase
Reposted from Perricone MD
Perricone MD response
Thank you so much for your kind words!

Most helpful critical review

Sept 8, 2024
Not for me
[This review was collected as part of a promotion.] I've never used a smoothing serum before, but I'm approaching my late 30s and thought I needed to start. Unfortunately I started breaking out and had to stop using it. It isn't a good product for me.
Jessie
Reposted from perriconemd.com
5 stars
77%
4 stars
20%
3 stars
3%
2 stars
1%
1 star
0%
Sort by Most Helpful
Kelli
Reposted from Perricone MD
Verified purchase
Feb 5, 2026
Smoothing serum
I’ve noticed a significant change in the texture of my skin, I’m obsessed!
Perricone MD response
Thank you so much for your kind words!
Sally N.
Reposted from Perricone MD
Verified purchase
Feb 3, 2026
Wonderful Smoothing Lotion
It's not a serum, but a light lotion. It feels just like the name implies - smoothing. I use it under my moisturizer and over my serums. I was so pleased I bought two (on a great sale) to stock up.
Perricone MD response
We love your insights. Keep them coming!
Al
Reposted from Perricone MD
Verified purchase
Jan 29, 2026
Totally recommend this serum
This serum leaves my skin plump and smooth. A little moisturizer after and I am ready for life. I totally recommend this serum.
Perricone MD response
Looking forward to seeing you again!
KAndrews580
Reposted from Perricone MD
Jan 16, 2026
just….WOW!
This is a MUST HAVE! Firmer, smoother, and younger looking. I had no idea a serum or lotion could work this well…and so quickly. I’ve said for years that if I could find a product that actually works, I’d pay whatever it took. This is one of those products. I LOVE this product.
Perricone MD response
Thank you for your wonderful review! Stay connected and keep sharing!
Anonymous
Reposted from Perricone MD
Verified purchase
Sept 24, 2025
Intensive smoothing serum
Love this produce make my skin smooth and bright. I get a lot of compliments on how smooth my skin looks even without foundation. Sharon
cookie
Reposted from Perricone MD
Jan 4, 2025
This really works!
I have (or had) a few deep wrinkles on my forehead and a few around my lips. After five weeks of continuous use they have greatly diminished. Finally a product does what it promised. Extremely happy I discovered this serum!
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