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Details & care
What it is: A mineral oil-free serum that targets aging signs.
What it does: Neuropeptides offer the ultimate visible antidote to wrinkles, sagging, dullness and discoloration. DMAE helps visibly lift sagging skin over time. Vitamin C ester gives the appearance of collagen-rich skin by visibly smoothing, brightening and minimizing discoloration.
How to use: After cleansing, massage onto your face and neck using a gentle upward motion. Wait until fully absorbed and follow with your favorite Perricone MD moisturizer. Use morning and evening.
- 1 oz.
- Mineral oil-free
- Made in the USA
- Item #5695590
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Perricone MD
Perricone MD founder Dr. Nicholas Perricone believes that true beauty comes from incredibly radiant health. The company's products use the most powerful ingredients on the planet, and are rooted in a holistic approach that is backed by science and research. Perricone MD never compromises on excellence and innovation because it's on a mission to revolutionize skin care for results you can see.
Most helpful positive review
May 9, 2026
Love!
I love love LOVE this product! It's so effective I cried when it was discontinued.
Jen
Verified purchase
Reposted from Perricone MD
Perricone MD response
Thank you for sharing your experience! We truly appreciate your support and your thoughtful feedback.
Most helpful critical review
Dec 22, 2022
Nope, don’t buy this
This is the BIGGEST waste of money honestly. I have used it for almost a month religiously morning and night. And nothing not even a slight change in texture, fine lines, redness- nothing at all. I am 42 and have taken care of my skin with medical grade products. I wanted to give this product a try to change things up a bit. BIG mistake, I do NOT recommend this product at all it’s worthless
Jamie
Verified purchase
Reposted from Perricone MD
5 stars
85%
4 stars
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Sort by Most Helpful
Jen
Reposted from Perricone MD
Verified purchase
May 9, 2026
Love!
I love love LOVE this product! It's so effective I cried when it was discontinued.
Perricone MD response
Thank you for sharing your experience! We truly appreciate your support and your thoughtful feedback.
Sharon
Reposted from Perricone MD
Verified purchase
Jan 29, 2026
Love this product
I’m so pleased with this product !!! It’s crazy how wonderful each products works to your skin.
Perricone MD response
Don’t hesitate to share your thoughts any time!
Anonymous
Reposted from Perricone MD
Verified purchase
Jan 15, 2026
Superior Product
This product builds and retains a plump smooth bright appearance. This effect lasts for days without product
Perricone MD response
Looking forward to hearing more feedback from you!
Dawn
Reposted from Perricone MD
Verified purchase
Jan 12, 2026
Great Product
I really like how this product feels on my face.It goes on smoothly and I can’t imagine not using it.
Perricone MD response
We love your insights. Keep them coming!
Hpb
Reposted from Perricone MD
Verified purchase
Jan 3, 2026
This is a great product
Wonderful product, leaves my face soft and moisturized
Perricone MD response
Hope to see more reviews from you!
? Forgot
Reposted from Perricone MD
Verified purchase
Dec 3, 2025
Reliable product
Have used this product for many years, very happy with it results👍
Perricone MD response
Thank you so much for your honest feedback! We’re thrilled to hear that you are liking the Neuropeptide Smoothing Facial Conformer and are happy with the results. Your support truly means so much and we are so glad you are part of our Perricone MD family.