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Details & care
What it is: An oil-free firming moisturizer that helps combat signs of aging.
What it does: Neuropeptides offer the ultimate visible antidote to wrinkles, sagging, dullness and discoloration, while DMAE helps visibly lift sagging skin over time. Hyaluronic acid provides essential hydration for visibly plumper skin.
How to use: Massage onto a cleansed face and neck using a gentle upward motion. Use morning and evening. For best results, apply after your favorite Perricone MD serum, serum concentrate or facial cream .
- 2 oz.
- Oil-free
- Made in the USA
- Item #5695570
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Perricone MD
Perricone MD founder Dr. Nicholas Perricone believes that true beauty comes from incredibly radiant health. The company's products use the most powerful ingredients on the planet, and are rooted in a holistic approach that is backed by science and research. Perricone MD never compromises on excellence and innovation because it's on a mission to revolutionize skin care for results you can see.
Most helpful positive review
Aug 29, 2025
Nothing short of amazing
I stumbled upon this product and fell in love. The texture is wonderful, and it smells amazing. It absorbs quickly and easily into my skin making my skin feel super hydrated. It's definitely of one my favs.
HWatkins
Reposted from Perricone MD
Perricone MD response
Thank you, for your kind words on our product "Neuropeptide Firming Moisturizer" It's a honest pleasure knowing the product helped and has hydrated your skin. We hope to see more reviews from you!
Most helpful critical review
Dec 17, 2025
Nearly Suffocating Fumes!
Unfortunately, it's in the Trash! I bought it years ago, and not sure if it really made a difference. I bought it again RECENTLY because I needed a moisturizer and it seemed to be *** 10% moisturizer and 90% Fragrance!!! I didn't have time to go through returns, so it's in the trash.
Regrets
Reposted from Perricone MD
Perricone MD response
Thank you for your review. I am so very sorry to hear this and your feedback has been passed on to the relevant team. Thank you.
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Sort by Most Helpful
Cari D
Verified purchase
Aug 23, 2023
Melted to a Liquid
Product arrived melted. I’m skeptical the chemical ingredients are as potent once they’ve been subjected to heat that changes the composition of the matter from a solid to a liquid.
1found this helpful
Regrets
Reposted from Perricone MD
Dec 17, 2025
Nearly Suffocating Fumes!
Unfortunately, it's in the Trash! I bought it years ago, and not sure if it really made a difference. I bought it again RECENTLY because I needed a moisturizer and it seemed to be *** 10% moisturizer and 90% Fragrance!!! I didn't have time to go through returns, so it's in the trash.
Perricone MD response
Thank you for your review. I am so very sorry to hear this and your feedback has been passed on to the relevant team. Thank you.
HWatkins
Reposted from Perricone MD
Aug 29, 2025
Nothing short of amazing
I stumbled upon this product and fell in love. The texture is wonderful, and it smells amazing. It absorbs quickly and easily into my skin making my skin feel super hydrated. It's definitely of one my favs.
Perricone MD response
Thank you, for your kind words on our product "Neuropeptide Firming Moisturizer" It's a honest pleasure knowing the product helped and has hydrated your skin. We hope to see more reviews from you!
Kim5
Reposted from perriconemd.com
June 16, 2022
A keeper.
[This review was collected as part of a promotion.] This cream does all that it claims. The neuropeptide line in general is unbeatable.
Dr. Perricone for those of us with serious nut allergies particularly macadamia and shea, and increasingly so in your reformulated products, I can't use them. I have loved your AcylGlutathione eyelid serum for years. Your new formulation has macadamia and I can't use it.
Kathleen1
Reposted from perriconemd.com
June 16, 2022
Lifetime User!!
[This review was collected as part of a promotion.] After cleaning/prepping my face with a quick wash of charcoal micellar water, I coat my face and neck with Neuropeptide Firming Moisturizer. I very lightly massage it in, with much of the product still visible on my skin. I let it absorb on it's own prior to bedtime. My skin looks happy and healthy every morning!!
Liang
Reposted from perriconemd.com
June 16, 2022
I will never buy this again
[This review was collected as part of a promotion.] This product is not that moisturizing, and it is not easy to be absorbed.