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Details & care
What it is: A powerful day to night antiwrinkle serum that includes the highest potency of Perricone MD's signature sciences.
What it does: This serum is formulated with Dr. Perricone's next generation polyamide technology, encapsulated retinol and eggshell membrane to help visibly lift and improve skin plumpness, cushion, bounce and resiliency.
Key ingredients:
- Polyamine Growth Factor: an endogenous molecule that improves the feel of skin elasticity and helps promote the look of youthful, collagen-rich and visibly firmer skin by replenishing moisture
- Encapsulated retinol: a stabilized form of retinol, this ultrapowerful, nonprescription vitamin A derivative replenishes the look of thin, collagen-depleted skin by accelerating surface skin exfoliation and renewal
- Eggshell membrane: a thin, water-soluble layer that lines an eggshell helps support the skin's moisture barrier and provide skin with a youthful texture and radiance by improving the feel of elasticity over time
How to use: After cleansing, massage onto your face and neck using gentle upward motions. Wait until fully absorbed and follow with your favorite moisturizer. Use morning and evening.
- 2 oz.
- Cruelty-free
- Made in the USA
- Item #5938673
Ingredients
Water/Aqua/Eau, Butylene Glycol, Heptyl Undecylenate, Lecithin, Alcohol Denat., Polymethyl Methacrylate, Niacinamide, Pentaerythrityl Adipate/ Caprate/Caprylate/Heptanoate, Phosphatidylcholine, Ascorbyl Palmitate, Hydrolyzed Egg Shell Membrane, Tricaprylin, Retinol, Tocopherol, BHT, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Dipropylene Glycol, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Cetearyl Alcohol, Stearic Acid, Caprylyl Glycol, Glyceryl Stearate, PEG-100 Stearate, Spermidine, Sodium Polyacrylate, Phenoxyethanol, Fragrance/Parfum, Limonene, Linalool, Hydroxycitronellal, Citronellol, Benzyl Alcohol, Geraniol
Ingredients are subject to change at the manufacturer's discretion. For the most complete and up-to-date list of ingredients, refer to the product packaging
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Perricone MD
Perricone MD founder Dr. Nicholas Perricone believes that true beauty comes from incredibly radiant health. The company's products use the most powerful ingredients on the planet, and are rooted in a holistic approach that is backed by science and research. Perricone MD never compromises on excellence and innovation because it's on a mission to revolutionize skin care for results you can see.
Most helpful positive review
Feb 12, 2026
Skin essential.
I love this serum. Very light, gives my skin a soft smooth feel and even tone. Don't understand why it’s out of stock. Please bring it back. It’s a little too pricey though!
GP
Reposted from Perricone MD
Perricone MD response
Looking forward to hearing more feedback from you!
Most helpful critical review
Sept 26, 2025
Allergy warning
***CONTAINS EGGS*** Egg allergy warning. I student hugged me (k teacher) goodbye after hugging her mother. A 911 call and a trip to the ER later, her mom remembered she had just put on this product. Be mindful if anyone you know is allergic to eggs.
K-Teacher
Reposted from Perricone MD
Perricone MD response
We do apologize for any inconvenience this may have caused. We would definitely recommend all our customers to go through the ingredients list before making any purchases to identify any such ingredient that probably may cause a reaction. You can also speak to our skin scare specialist team at 888-450-2887 so we can assist with product information. We would like to also take the second and thank you for this very insightful review.
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Sort by Most Helpful
Mobaymama
Sept 8, 2021
Contains retinol
I was looking for a growth factor serum a little less pricey than Neocutis so I was excited to find and try this. My mistake in not reading the ingredients and using it before realizing that this serum contains retinol. I'm already on a tretinoin regimen (which is stronger than the retinol contained in this serum). I'm also not happy about fragrance being added to this. I stopped using my tretinoin and decided to try it out since I already had it, but I think my skin does much better with tretinoin. I think I'll go back to Neocutis growth factor serum which doesn't contain retinol.
14found this helpful
GP
Reposted from Perricone MD
Feb 12, 2026
Skin essential.
I love this serum. Very light, gives my skin a soft smooth feel and even tone. Don't understand why it’s out of stock. Please bring it back. It’s a little too pricey though!
Perricone MD response
Looking forward to hearing more feedback from you!
Jaclyn
Reposted from Perricone MD
Verified purchase
Jan 2, 2026
Why I look 20 years younger than I am!
Been using this for over 20 years. It's why I look 20 years younger than I am with firm, plump, flawless skin.
Perricone MD response
We’ll eagerly await your next review!
Mikki
Reposted from Perricone MD
Verified purchase
Dec 31, 2025
Worth every penny!
My skin has never felt or looked better! You get what you pay for and this is worth every penny!
Perricone MD response
It’s always a joy to hear from happy customers. We’re so glad we could deliver a great experience!
grandma
Reposted from Perricone MD
Verified purchase
Nov 15, 2025
Wrinkle softening
I was maybe a bit too hopeful. I'm still using it and I will give it another month.
Perricone MD response
Thank you for sharing your feedback with us. We truly appreciate you taking the time to let us know your thoughts, and we will be sure to pass this along to the relevant team.
Lizi from Texas
Reposted from Perricone MD
Verified purchase
Nov 15, 2025
I LOVE LOVE LOVE
High Potency Growth Factor Firmi
I LOVE LOVE LOVE
High Potency Growth Factor Firming & Lifting Serum. Thank you for bringing it back. It was not available for about 6 months. I was worried. My reserves was getting low. I stocked up now and have 6 bottles. This product makes my skin look great. Please keep this item in stock. Try this product you will love it too!
Perricone MD response
Thank you so much for taking the time to share your experience. We’re so thrilled to hear that you're loving the High Potency Growth Factor Firming & Lifting Serum and are happy with the results. Knowing that it has earned a special place in both your routine and your recommendations is incredibly meaningful to us. We’re truly grateful for your support.