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Details & care
What it is: An oil-free serum formulated with hyaluronic acid to help provide essential hydration for visibly plumper skin.
What it does: DMAE helps visibly lift sagging skin over time, while alpha lipoic acid reduces the appearance of lines, wrinkles and enlarged pores.
How to use: After cleansing, massage onto your face and neck using a gentle upward motion. Wait until fully absorbed and follow with your favorite moisturizer. Use morning and evening.
- 2 oz.
- Oil-free
- Made in the USA
- Item #5695567
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Perricone MD
Perricone MD founder Dr. Nicholas Perricone believes that true beauty comes from incredibly radiant health. The company's products use the most powerful ingredients on the planet, and are rooted in a holistic approach that is backed by science and research. Perricone MD never compromises on excellence and innovation because it's on a mission to revolutionize skin care for results you can see.
Most helpful positive review
Mar 31, 2026
Best Serum Perricone Ever Made
I will continuously search for this serum. It's an OG, from when The Doctor was still formulating. (used to be called Formula 15, to celebrate an anniversary)
It smooths skin texture, great for 40s, when you really need to act to prevent deepening lines and pores.
Once a day is plenty. Always apply SPF on top.
Please NEVER discontinue, I have had this in my life for a decade and no one guesses my age... usually 15 years younger than I am.
E Jazz
Reposted from Perricone MD
Perricone MD response
We love hearing this! A decade of Formula 15 magic and still turning back the clock—your secret’s safe with us. Here’s to many more years of glowing skin!
Most helpful critical review
Jan 8, 2026
Horrible smell!
Several years ago I used two products regularly. Was so pleased with the results. This product has such a horrible smell as it dries that I can’t use it! Total waste of money.
Marsha
Verified purchase
Reposted from Perricone MD
Perricone MD response
Thank you for taking the time to share your experience. We truly regret that the High Potency Classics Face Firming Serum did not meet your expectations. Please check your Perricone MD account messages as we have emailed you to discuss this further.
5 stars
44%
4 stars
34%
3 stars
14%
2 stars
2%
1 star
6%
Sort by Most Helpful
E Jazz
Reposted from Perricone MD
Mar 31, 2026
Best Serum Perricone Ever Made
I will continuously search for this serum. It's an OG, from when The Doctor was still formulating. (used to be called Formula 15, to celebrate an anniversary)
It smooths skin texture, great for 40s, when you really need to act to prevent deepening lines and pores.
Once a day is plenty. Always apply SPF on top.
Please NEVER discontinue, I have had this in my life for a decade and no one guesses my age... usually 15 years younger than I am.
Perricone MD response
We love hearing this! A decade of Formula 15 magic and still turning back the clock—your secret’s safe with us. Here’s to many more years of glowing skin!
Kh
Reposted from Perricone MD
Jan 18, 2026
Had a bad reaction
I wanted to love this product and think it did cause my skin have a glow. Unfortunately I had a bad reaction to it after patch testing and now have itchy raised red bumps on my face. So have stopped using the product immediately.
Perricone MD response
Thank you so much for your feedback. We regret that the High Potency Classics Face Firming Serum did not meet your expectations. We would appreciate the opportunity to discuss this further and provide a resolution. Please contact us at (844) 334-9398 or through your Perricone MD account at your earliest convenience.
Marsha
Reposted from Perricone MD
Verified purchase
Jan 8, 2026
Horrible smell!
Several years ago I used two products regularly. Was so pleased with the results. This product has such a horrible smell as it dries that I can’t use it! Total waste of money.
Perricone MD response
Thank you for taking the time to share your experience. We truly regret that the High Potency Classics Face Firming Serum did not meet your expectations. Please check your Perricone MD account messages as we have emailed you to discuss this further.
Svitlana
Reposted from Perricone MD
Verified purchase
Jan 6, 2026
Very good
I really like it, I love this brand. I sincerely recommend it to everyone
Perricone MD response
Hello, we are delighted you liked this product and we thank you for sharing such a valuable feedback :)
CAL
Reposted from Perricone MD
Verified purchase
Dec 30, 2025
You look lovely
Light and fresh on the skin
Deeply smoothing nourishment
Elegant youthfulness everyday
Perricone MD response
Such a great review, thank you for the lovely feedback.
Karen
Reposted from Perricone MD
Verified purchase
Dec 8, 2025
It works!
I have been using the Dr. Perricone products since they first came out in !997- yes I must be old, 81 in fact. I always get compliments on my skin and always get taken for much younger .I attribute it to DMAE as my favorite . The face firmingmserum I really can’t be without. It works!