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Details & care
What it is: A powerful, rejuvenating moisturizer with a formula that targets deep wrinkles and creases.
What it does: Acyl glutathione helps reduce the look of deep wrinkles and creases by protecting and replenishing fragile skin. A vitamin F blend from flaxseed, chia seed and macadamia nut oils works over time to restore suppleness and create a healthy glow by intensely moisturizing and improving skin's moisture barrier.
How to use: Massage onto a cleansed face and neck using a gentle upward motion. Use morning and evening. For best results, apply after your Perricone MD serum, serum concentrate or facial cream.
- 1 oz.
- Made in the USA
- Item #5695585
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Perricone MD
Perricone MD founder Dr. Nicholas Perricone believes that true beauty comes from incredibly radiant health. The company's products use the most powerful ingredients on the planet, and are rooted in a holistic approach that is backed by science and research. Perricone MD never compromises on excellence and innovation because it's on a mission to revolutionize skin care for results you can see.
Most helpful positive review
July 31, 2025
Need Restock! Best moisturizer ever 2yr user
This has been out of stock for over 6 months is it coming back or discontinued. I use it every single day. My skin has never looked better its the only moisturizer I can use every day, the night one is a little to heavy for daily use in Vegas. Please RESTOCK !!! The ingredients are great for eczema issues as well.
Coastie
Reposted from Perricone MD
Perricone MD response
Thank you for taking the time to share your positive experience with us. We’re so pleased to hear that Essential Fx Acyl-Glutathione Rejuvenating Moisturizer made a difference for you. Your satisfaction is our top priority, and your review reaffirms the hard work we put in every day. Looking forward to seeing you again!
Most helpful critical review
Jan 27, 2020
New formula stinks- literally
I have used this cream for about 7 years and have always loved it. Then they reformulated it and I hate it. The smell is awful and the texture is different. I tried 3 different jars thinking maybe it was me or a bad batch, it wasn’t. It’s the new formula. Big bummer because it was so awesome and a great price point. I’m on the hunt for something new now.
Mountaingirl32
5 stars
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4 stars
22%
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5%
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Sort by Most Helpful
Coastie
Reposted from Perricone MD
July 31, 2025
Need Restock! Best moisturizer ever 2yr user
This has been out of stock for over 6 months is it coming back or discontinued. I use it every single day. My skin has never looked better its the only moisturizer I can use every day, the night one is a little to heavy for daily use in Vegas. Please RESTOCK !!! The ingredients are great for eczema issues as well.
Perricone MD response
Thank you for taking the time to share your positive experience with us. We’re so pleased to hear that Essential Fx Acyl-Glutathione Rejuvenating Moisturizer made a difference for you. Your satisfaction is our top priority, and your review reaffirms the hard work we put in every day. Looking forward to seeing you again!
Michele
Reposted from Perricone MD
Verified purchase
May 15, 2024
rejuvenating moisturizer
Love this moisturizer! Absorbs so nicely, and my skin feels great all day long!
Kate
Reposted from perriconemd.com
Dec 10, 2023
I can't live without this product
I'm not exaggerating, if I try anything else (I've tried just about everything) my skin breaks out. This cream is a life saver for me. No breakouts, very moisturizing & perfect for my combination skin!
Becky
Reposted from Perricone MD
July 26, 2023
Essential FX Acyl-Glutathione
Love the smell of this product when first put it on !!! Noticeable difference in deeper wrinkles that were in my neck & decollete area. Very pleased with the difference this product makes.
Becky
Reposted from perriconemd.com
July 25, 2023
Essential FX Acyl-Glutathione
Love the smell of this product when first put it on !!! Noticeable difference in deeper wrinkles that were in my neck & decollete area. Very pleased with the difference this product makes.
Elysia
Reposted from Perricone MD
Verified purchase
June 18, 2023
Ordering Again Right Now!
If you are looking for a great face cream that doesn't take forever to make a difference on wrinkles this is it. I really can't say enough about it and can't say anything negative.