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C&E Advanced with Hexylresorcinol and Silymarin Treatment Cream

PCA Skin

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Details & care

What it is: An advanced antioxidant formula that diminishes dark spots, soothes irritated skin and reduces signs of aging.

What it does: It's formulated with proven therapeutic levels of L-ascorbic acid and tocopheral and also contains the advanced corrective ingredients hexylresorcinol and silymarin. Its stable anhydrous formula prevents antioxidant degradation. This treatment helps leave skin brightened with an even tone, and helps reduce future discoloration. It also contains skin-calming and brightening benefits and helps fight free radical damage.

How to use: Apply to the skin once daily in the morning. After cleansing, toning and applying any treatment serums, apply to the face and neck in the morning. You might experience a slight tingling sensation upon application. Follow with your broad-spectrum SPF product in the daytime and moisturizer in the evening.

  • 1 oz.
  • Paraben-free; phthalate-free; synthetic dye-free; synthetic fragrance-free; mineral oil-free; petrolatum-free; lanolin-free
  • Made in the USA
  • Item #5771295
  • Core Product ID 333335JG3V

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PCA SKIN

PCA SKIN was founded in 1990, a collaboration between an aesthetician and a dermatologist. The company's product development and quality-assurance processes go above and beyond industry standard, and its formulas are researched and formulated by an in-house chemist. PCA SKIN has solutions to address a wide variety of skin types and conditions, and its products create visible results.

Reviews

(124)1244.3 out of 5
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Most helpful positive review

May 23, 2026

Love this serum!

This serum has a velvet-like texture and glides on effortlessly. My skin texture has never been smoother at age 60. A little bit goes a long way and I do experience a slight tingling sensation during application, but that quickly goes away. I only use this at night immediately after cleansing my face and neck. Also, this serum has done a great job fading dark spots, especially on my neck. I highly recommend adding this to your daily face care routine.
Nancey R
Verified purchase
Reposted from PCAskin

Most helpful critical review

Jan 12, 2025

Questionable 🤨

Very gritty and grainy texture that feels like it is not absorbing, and rough on my skin. More like an exfoliation than a serum. Very drying, really don’t like how the application feels and I agree with the comment that it comes out separated out of the tube, liquid then cream. I shake it vigorously to avoid this from happening. All my skincare is PCA. I did send in an email about my concern but haven’t heard back, it’s only been a couple days though. Hopefully they can help ☺️
Glowing
Reposted from PCAskin

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5 stars65%
4 stars14%
3 stars11%
2 stars6%
1 star4%
June 27, 2026

So far so good

I’m not quite through with my first tube. So far I like it a lot. After reading some comments about difficulty in application I started mixing it with my pro peptide serum. It goes on very easily and I can still feel the tingle. I love all the PCA skin products I’ve tried so far. They completely absorb which is the point of all skin products.
Reposted from PCAskin
Verified purchase
NoName2
May 23, 2026

Love this serum!

This serum has a velvet-like texture and glides on effortlessly. My skin texture has never been smoother at age 60. A little bit goes a long way and I do experience a slight tingling sensation during application, but that quickly goes away. I only use this at night immediately after cleansing my face and neck. Also, this serum has done a great job fading dark spots, especially on my neck. I highly recommend adding this to your daily face care routine.
Reposted from PCAskin
Verified purchase
Nancey R
May 1, 2026

Great!

My esthetician recommended incorporating this into my morning routine. Love the orange smell and have noticed my skin does look clear since using this for a few weeks
Reposted from PCAskin
Verified purchase
Anonymous
Mar 23, 2026

Best Vitamin C on the Market

My career has been selling aesthetic medicine into Dermatology and Plastic surgery. It is by far the best vitamin C on the market. It is the purest form of Vitamin C and at 20%. It is the only Vitamin C on the market that I am aware of that does not contain water as part of the ingredients. Water is the #1 element that degrades vitamin C, followed by light. If you are not seeing results with your current Vitamin C, you should give this a try - always give dermatology products at least 30 days ( a skin cycle) before abandoning a product. This has been a game changer for my aged and sun-damaged skin. It is expensive but worth every penny. Don't cheap ou t on your viatmin C product. You can spend less on HA and moisturizer, but not Vitamin C - they are not all equal. You may not like the spreadability at first ( being honest) because it doesn't have an aqueous ( water) base - but thats why it is so highly effective. You'll come to love it.
Reposted from PCAskin
Verified purchase
Anonymous
Mar 10, 2026

Absolutely AMAZING

In just 5 days I noticed my frown lines disappearing and my freckles lightening!! After just 2 weeks it changed my skin tone completely and all over brighter and firmer. The furrow lines are actually gone, as long as i dont frown! I'm aging backwards !!! Vitamin c&e really works. It does sting though, and I realized that the penetrating of the outer layer is what makes it work. Now I appreciating the stinging.. I like to think that it is like getting laser treatment but much cheaper and quite effective. I am soooo happy. I will stick with this product the rest of my life!
Reposted from PCAskin
Jj1k
Feb 7, 2026

Dark Spot Lighter

I am remaining hopeful that this product continues to lighten the dark spot on the side of my face. I am seeing a slow but noticeable difference. I will keep using it and will definitely get more product when the time comes. I do use a different brand at night since the C&E Advanced says to only use during the day. I need a daytime pigment product from PCA. Any recommendations?
Reposted from PCAskin
Verified purchase
elizette