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Details & care
What it is: A highly potent, silky serum that uses neuropeptides to smooth the look of lines and wrinkles around the mouth, eyes, lips and forehead.
What it does: This highly potent serum smoothes the look of even the most stubborn, deep lines, wrinkles and creases around the mouth, eyes, lips and forehead, including marionette lines, frown lines, smile lines and nasolabial folds. Over time, wrinkle depth appears shallower and the look of expression lines reduced.
Key ingredient:
- Neuropeptides: powerful, protein-like building blocks with a unique chemical structure that supports the skin barrier and hydration
How to use: After cleansing, massage onto face and neck using a gentle upward motion. Wait until fully absorbed and follow with your favorite Perricone MD moisturizer. Use morning and evening.
- 1 oz.
- Paraben-free; phthalate-free; sulfate-free
- Made in the USA
- Item #11104899
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Perricone MD
Perricone MD founder Dr. Nicholas Perricone believes that true beauty comes from incredibly radiant health. The company's products use the most powerful ingredients on the planet, and are rooted in a holistic approach that is backed by science and research. Perricone MD never compromises on excellence and innovation because it's on a mission to revolutionize skin care for results you can see.
Most helpful positive review
Apr 21, 2026
Loving This!
This really does help the deep lines around my mouth. One would think since I have had these lines for so many years, they would be ingrained. But I can tell an improvement in a month.
Vicki Latham
Verified purchase
Reposted from Perricone MD
Perricone MD response
Thank you for sharing your experience! It’s great to know the product is making a noticeable difference for you!
Most helpful critical review
Mar 3, 2026
Nope
[This review was collected as part of a promotion.] I have combination skin leaning more towards dry living here in AZ. Will it get rid of your wrinkles? No. But is it really moisturizing? Also no. This was a fail for me. The serum is too think for the dropper. Just give me a pump! I have no results or changes in skin after a month. If anything it dried out my skin more.
AmyE
Reposted from influenster.com
5 stars
65%
4 stars
23%
3 stars
9%
2 stars
2%
1 star
1%
Sort by Most Helpful
Vicki Latham
Reposted from Perricone MD
Verified purchase
Apr 21, 2026
Loving This!
This really does help the deep lines around my mouth. One would think since I have had these lines for so many years, they would be ingrained. But I can tell an improvement in a month.
Perricone MD response
Thank you for sharing your experience! It’s great to know the product is making a noticeable difference for you!
KristiC
Reposted from influenster.com
Apr 19, 2026
Luxe addition to skincare routine
[This review was collected as part of a promotion.] It feels lightweight and smooth on the skin, and it sinks in pretty quickly without leaving behind any sticky or greasy feeling. It layers well with the rest of my skincare too, which I always appreciate.
It definitely has that luxe, high-end feel, both in the formula and the packaging. My skin feels softer and more hydrated after using it.
Anonymous
Reposted from Perricone MD
Verified purchase
Apr 10, 2026
Deep Crease Serum
This product is awesome. I started noticing creases around my mouth and use this twice a day and they have really started to fade. 5 stars!!
Perricone MD response
That’s really great to hear! It sounds like it’s making a noticeable difference for you with consistent use. Always encouraging when a product starts to visibly smooth things out over time.
MP05
Reposted from influenster.com
Apr 6, 2026
Premium product, premium results
[This review was collected as part of a promotion.] Once again, Influenster and Dr Perricone comes along with a phenomenal product! Thai was given to me to try and let me tell you, what a great, easy, premium product this is! First- it’s unavoidable to mention it is a premium product with a premium price point. BUT- it responds with premium results! I started using this as my go to serum, preceded by my face wash, toner and essence. After those steps, I apply a reasonable amount of this (about half a dime sized drop) and I applied it to the sides of my nose, where smile lines are. It absorbs nicely and isn’t sticky or tacky. I finish with a simple moisturizer and that’s it. At first, no big deal… but after about 2 weeks, I have noticed some softening of these crease lines. Mind you I’ve had them a while, so I’m definitely managing expectations here. But the fact that after only 2 weeks I’ve seen them start to soften, and from a topical- I’ll take it! I’m eager to see how it goes in 2 months. I really appreciate that this is a very smooth, absorbable serum. No issues with pilling or feeling heavy. I am a bit concerned about the maintenance once I finish this, as it is a truly premium priced product, but if it works, it’s definitely a lot less than injectables and cos med interventions. I’ll keep applying it and look forward to the results!
Meg
Reposted from Perricone MD
Verified purchase
Apr 4, 2026
Great
I brought a month ago so pleased I did, can notice a bug difference, less deep wrinkles.
Perricone MD response
That's fantastic to hear! We're so glad you’re seeing a noticeable difference and those deep wrinkles are less visible. Thank you for sharing your experience, your results make us so happy.
BrittaN
Reposted from influenster.com
Mar 30, 2026
Such a gentle serum- love it!
[This review was collected as part of a promotion.] I tried this serum because of my smile lines and was pleasantly surprised.
It’s lightweight but still hydrating and with regular use those lines look a lot softer and less noticeable.
My skin feels firmer after all.
It’s not an overnight fix but I did see a difference over time.