Current Price $189.00
Gift with Purchase
DetailsDetails & care
What it is: A highly potent, silky serum that uses neuropeptides to smooth the look of lines and wrinkles around the mouth, eyes, lips and forehead.
What it does: This highly potent serum smoothes the look of even the most stubborn, deep lines, wrinkles and creases around the mouth, eyes, lips and forehead, including marionette lines, frown lines, smile lines and nasolabial folds. Over time, wrinkle depth appears shallower and the look of expression lines reduced.
Key ingredient:
- Neuropeptides: powerful, protein-like building blocks with a unique chemical structure that supports the skin barrier and hydration
How to use: After cleansing, massage onto face and neck using a gentle upward motion. Wait until fully absorbed and follow with your favorite Perricone MD moisturizer. Use morning and evening.
- 1 oz.
- Paraben-free; phthalate-free; sulfate-free
- Made in the USA
- Item #11104899
Shipping & returns
Free shipping. Free returns. All the time. Purchases made online can also be returned or exchanged at any Nordstrom store, free of charge. Read more about our shipping & returns policies.
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- Fabric gift bag ($5)
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Perricone MD
Perricone MD founder Dr. Nicholas Perricone believes that true beauty comes from incredibly radiant health. The company's products use the most powerful ingredients on the planet, and are rooted in a holistic approach that is backed by science and research. Perricone MD never compromises on excellence and innovation because it's on a mission to revolutionize skin care for results you can see.
Most helpful positive review
May 3, 2026
Buy it!
Too early to see long lasting results BUT it definitely has helped my skin’s appearance
TR
Verified purchase
Reposted from Perricone MD
Perricone MD response
Hello, we are delighted you liked this product and we thank you for sharing such a valuable feedback :)
Most helpful critical review
Mar 3, 2026
Nope
[This review was collected as part of a promotion.] I have combination skin leaning more towards dry living here in AZ. Will it get rid of your wrinkles? No. But is it really moisturizing? Also no. This was a fail for me. The serum is too think for the dropper. Just give me a pump! I have no results or changes in skin after a month. If anything it dried out my skin more.
AmyE
Reposted from influenster.com
5 stars
65%
4 stars
23%
3 stars
9%
2 stars
2%
1 star
1%
Sort by Most Helpful
Size
MyL8
Reposted from influenster.com
May 3, 2026
Hydrate well, softens lines, expensive, subtle result.
[This review was collected as part of a promotion.] I have been using this serum for a few weeks, it definitely feels rich and highend. The texture is silky but slightly thick, and my skin looks more hydrated and smoother right after applying. I noticed some softening of fine lines, especially around my mouth and forehead, but deep crease are still there, just less noticeable. Strong hydration, smoother texture and gradual firming. However, the price is high and little heavy feel, and subtle, not dramatic result.
TR
Reposted from Perricone MD
Verified purchase
May 3, 2026
Buy it!
Too early to see long lasting results BUT it definitely has helped my skin’s appearance
Perricone MD response
Hello, we are delighted you liked this product and we thank you for sharing such a valuable feedback :)
JC
Reposted from Perricone MD
Verified purchase
Apr 30, 2026
W0orks great
I have a deep crease from a scar and it lifts up the crease.
Perricone MD response
Thank you for sharing your experience. We truly appreciate your support!
Gini
Reposted from Perricone MD
Verified purchase
Apr 28, 2026
My favorite serum
I am really loving the deep crease serum. I'll be 58 soon and this serum has improved the look of my fine lines and deeper nasal fold wrinkles. It feels really good on my skin. The only complaint is the dropper doesn't pick up the product very well.
Perricone MD response
Thank you for your feedback.
We regret that the product did not meet your expectations. We would appreciate the opportunity to discuss this further and provide a resolution.
If you wouldn't mind giving us a call at (844)334-9398 at the earliest convenience, looking forward to talking to you.
Vicki Latham
Reposted from Perricone MD
Verified purchase
Apr 21, 2026
Loving This!
This really does help the deep lines around my mouth. One would think since I have had these lines for so many years, they would be ingrained. But I can tell an improvement in a month.
Perricone MD response
Thank you for sharing your experience! It’s great to know the product is making a noticeable difference for you!
KristiC
Reposted from influenster.com
Apr 19, 2026
Luxe addition to skincare routine
[This review was collected as part of a promotion.] It feels lightweight and smooth on the skin, and it sinks in pretty quickly without leaving behind any sticky or greasy feeling. It layers well with the rest of my skincare too, which I always appreciate.
It definitely has that luxe, high-end feel, both in the formula and the packaging. My skin feels softer and more hydrated after using it.
