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Details & care
What it is: A highly potent, silky serum that uses neuropeptides to smooth the look of lines and wrinkles around the mouth, eyes, lips and forehead.
What it does: This highly potent serum smoothes the look of even the most stubborn, deep lines, wrinkles and creases around the mouth, eyes, lips and forehead, including marionette lines, frown lines, smile lines and nasolabial folds. Over time, wrinkle depth appears shallower and the look of expression lines reduced.
Key ingredient:
- Neuropeptides: powerful, protein-like building blocks with a unique chemical structure that supports the skin barrier and hydration
How to use: After cleansing, massage onto face and neck using a gentle upward motion. Wait until fully absorbed and follow with your favorite Perricone MD moisturizer. Use morning and evening.
- 1 oz.
- Paraben-free; phthalate-free; sulfate-free
- Made in the USA
- Item #11104899
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Perricone MD
Perricone MD founder Dr. Nicholas Perricone believes that true beauty comes from incredibly radiant health. The company's products use the most powerful ingredients on the planet, and are rooted in a holistic approach that is backed by science and research. Perricone MD never compromises on excellence and innovation because it's on a mission to revolutionize skin care for results you can see.
Most helpful positive review
Mar 30, 2026
Such a gentle serum- love it!
[This review was collected as part of a promotion.] I tried this serum because of my smile lines and was pleasantly surprised.
It’s lightweight but still hydrating and with regular use those lines look a lot softer and less noticeable.
My skin feels firmer after all.
It’s not an overnight fix but I did see a difference over time.
BrittaN
Reposted from influenster.com
Most helpful critical review
Mar 3, 2026
Nope
[This review was collected as part of a promotion.] I have combination skin leaning more towards dry living here in AZ. Will it get rid of your wrinkles? No. But is it really moisturizing? Also no. This was a fail for me. The serum is too think for the dropper. Just give me a pump! I have no results or changes in skin after a month. If anything it dried out my skin more.
AmyE
Reposted from influenster.com
5 stars
65%
4 stars
23%
3 stars
9%
2 stars
2%
1 star
1%
Sort by Most Helpful
BrittaN
Reposted from influenster.com
Mar 30, 2026
Such a gentle serum- love it!
[This review was collected as part of a promotion.] I tried this serum because of my smile lines and was pleasantly surprised.
It’s lightweight but still hydrating and with regular use those lines look a lot softer and less noticeable.
My skin feels firmer after all.
It’s not an overnight fix but I did see a difference over time.
Judy
Reposted from Perricone MD
Mar 25, 2026
Wrinkles gone!
I’ve used this wrong mole treatment for almost one year. I’m 83 with hardly a deep wrinkle. It’s a miracle cream!!
Perricone MD response
We love hearing this—thank you for sharing your experience! So glad it’s been working so wonderfully for you.
AlisaJ
Reposted from influenster.com
Mar 22, 2026
Gentle results
[This review was collected as part of a promotion.] This serum is a good hydrator to help plump skin and as a result, reduce the visibility of creases. I used it awhile to ensure I could write an informed review, and while it didn’t eliminate any creases (I have one horizontal one on my neck plus deep nasolabial folds, those areas did appear smoother than before. The dropper was a little weird in that I could only get about one drop at a time but I guess it helped not waste product.
SarahZ
Reposted from influenster.com
Mar 19, 2026
High potent results
[This review was collected as part of a promotion.] This high potential deep crease serum if full of super power ingredients, neuro peptides, that helps smooth those pesky wrinkles. It’s a luxury product and you def get the results you’re looking for.
LeticiaB
Reposted from influenster.com
Mar 14, 2026
Does what it says.
[This review was collected as part of a promotion.] I am not new to Perricone MD products, so I was excited to try their deep crease serum. Especially, now that I’m older, I have seen a change in my skin. Especially the elasticity, texture, and increase in fine lines and wrinkles. I have deep smile lines that make my makeup application difficult. Using this product has made them smoother and less noticeable even without makeup use. These pictures are months apart and my no makeup look is much more improved than my makeup look. And this is without consistent nightly use. I’m very pleased with my results.
MSL
Reposted from Perricone MD
Verified purchase
Mar 14, 2026
Noticeable difference
I have been using for about a month and some of the wrinkles I have been concerned about are easing
Perricone MD response
Don’t hesitate to share your thoughts any time!