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  4. Dermatologist Recommended
(252)252

InstaFacial® Infusion Biomimetic Microcollagen Matrix

Dr. Diamond's Metacine

$325.00Current Price $325.00
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Highlights

  • Hyaluronic acid
  • Good for: Dullness
  • Best for: Normal skin

Details & care

What it is: A serum infused with a proprietary matrix of biomimetic microcollagen that works in harmony with your skin to amplify its natural collagen.

What it does: The serum helps visibly firm, lift and hydrate skin. It's the ultimate science-backed solution for youth preservation, providing both immediate and long-lasting improvement to skin's texture, elasticity and radiance. Driven by a thirst for innovation, Dr. Diamond leverages biotech advancements rooted in medical science to develop products that enhance the beauty and health of the skin. Engineered in a lab, Infusion is formulated with a human-identical matrix of microcollagen more consistent and more potent than those derived from plants or animals. Infusion combines three different types of human-identical microcollagen peptides to support the synthesis of Types I and III Collagens—those most responsible for youthful skin. Type I is the most abundant collagen in the body, a stiff protein that provides strength and structure. Type III is a webby protein that produces an elastic network or matrix, to provide structure and recoil to the skin.

Key ingredients:
- sh-POLYPEPTIDE-121: bioidentical to human Type XXI. Of the twenty-eight collagens in our bodies, this is a rare but essential collagen because it is a precursor to Types I & III
- sh-POLYPEPTIDE-123: bioidentical to human Type III
- sr-sh-POLYPEPTIDE-69 DIPEPTIDE-19: recombinant Type III with a low molecular weight for outstanding skin absorption

Research results: 32 women and 7 men from age 35-65 replaced their entire skin-care routine with InstaFacial® Infusion for 12 weeks. They were studied by a third party independent lab. They had both objective and subjective evaluations at baseline, 8 & 12 weeks:
- 81% of participants had improvement in skin extensibility (softness and suppleness)
- 56% of participants had improvement in skin elasticity *as measured by Cutometer Dual MPA 580
- 100% of subjects had improvement in skin hydration immediately, 96% at 8 weeks, 90% at 12 weeks *as measured by Corneometer CM 825
- 62% of subjects had improvement in transepidermal water loss
- 68% of subjects had improvement in fine lines at 8 weeks
- 37% of subjects had improvement in facial sagging at 8 weeks, 59% at 12 weeks

How to use: Apply 1-2 pumps of the serum on slightly damp skin morning and night.

  • Paraben-free; phthalate-free; sulfate-free; silicone-free; oil-free; fragrance-free
  • Made in the USA
  • Item #10700832
  • Core Product ID 333333RC46

Ingredients

Water Glycerin Dimethicone Pentylene Glycol Propanediol Niacinamide Simmondsia Chinesis (Jojoba) Seed Oil Giartina Stellata Extract Soluble Proteoglycan Myristoyl Pentapeptide-11 Sh-Polypeptide-121 Sh-Polypeptide-123 Sr-(Sh-Polypeptide-69 Dipeptide-19) Acetyl Tripeptide-108 N-Acetyl Lysyl Glutamine Myristoyl Pentapeptide-8 Squalane Sodium Hyaluronate Trehalose Diamond Powder Dimethicone Crosspolymer Beta-Glucan Hordeum Vulgare Seed Extract Phospholipids Xanthan Gum Hydroxyethyl Acrylate/Sodium Acryloyldimehtyl Taurate Copolymer Butylene Glycol Polysorbate 60 Phenoxyethanol Caprylyl Glycol Chlorphenesin 1,2-Hexanediol Sodium Benzoate Glyceryl Caprylate Glyceryl Undecylenate Potassium Sorbate
Ingredients are subject to change at the manufacturer's discretion. For the most complete and up-to-date list of ingredients, refer to the product packaging

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Dr. Diamond's Metacine

Dr. Diamond's Metacine

Reviews

(252)2524.6 out of 5
Write a Review

Most helpful positive review

July 15, 2026

Noticeable results

I have just started using the Instafacial Infusion and after 1 application there are noticeable differences.
Geri B.

Most helpful critical review

Mar 12, 2025

Not for me

[This review was collected as part of a promotion.] I've tried this product numerous times and didn't like the outcome This product stung and tingled my face. After using this product, it left my face sticky.
larhondad_8600

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5 stars71%
4 stars20%
3 stars6%
2 stars2%
1 star0%

Pros:

Cons:

Current reviews don’t mention any.
Aug 7, 2026

Good for sensitive skin

I have pretty reactive skin and this product hasn’t caused any issues. So far my skin feels more balanced and hydrated. Hopefully I’ll see more results soon. My only hesitation to continuing long term use is the cost of the product.
Malerie T.
July 15, 2026

Noticeable results

I have just started using the Instafacial Infusion and after 1 application there are noticeable differences.
Geri B.
July 6, 2026

Instinct gratification

I didn’t think this was going to be as effective as I thought it was going to be especially for the price of the serum, but I saw a difference in my skin within the first couple days of using it. That’s never happened before, even with other high-end serums. I would love to purchase this again the website has another sale!
Rozi
July 4, 2026

Morning and night

I love this product. Texture and overall performance. Leave my skin hydrated but not greasy. Improves the appearance of fine lines.
Laura
June 30, 2026

Great for elasticity

I have noticed a big difference in my skin’s overall appearance after using the infusion. The lower half of my face feels tightened and more sculpted.
Jordyn
June 21, 2026

Epic product, improved skin barrier, odd dispenser

Of all the Diamond products this one is probably the game changer. Morning and evening I have seen measurable improvement in my skin barrier and tightness. It’s literally a miracle serum. I can’t “feel” it working but the results are so obvious. This is the one! My only negative feedback is that the dispenser is so odd. I do have larger hands but I can’t imagine small hands even being able to get this to pump easily. Random egg shape and sometimes hard to get all the product out. It’s a small volume for a product that is recommended for morning and night, unlike the easy to dispense, larger volume or the emulsion.
Preston J.
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