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  3. Skin Care
  4. Serums & Treatments
(40)40

HydroStem+6 Stem Cell Antioxidant Serum

HydroPeptide

$175.00Current Price $175.00
1 Ounce
1 person viewing now
Free returns anytime
Sold by Nordstrom
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$60 off your next purchase—ends Dec. 1! Plus, earn 10 points per dollar Oct. 21–25. Terms apply. Apply Now

Highlights

  • Hyaluronic acid
  • Best for: Normal skin
  • Anti-aging

Details & care

What it is: A powerful anti-aging treatment that unites rejuvenating peptides with six antioxidant-rich botanical stem cells that guard against free-radicals.

What it does: With repeated use over time, you’ll notice your moisture balance increase thanks to high-performing hydrators, and your skin’s overall clarity improve while fine lines and wrinkles diminish. The formula also depends on a blend of amino peptides to enhance firmness and cell energy production; botanical stem cells to provide superior free-radical protection and delay signs of aging; niacin to reduce irritation and keep your skin hydrated and firm; and hyaluronic acid to smooth, hydrate and plump.

How to use: Morning and night after cleansing, apply a pea-sized amount to your entire face and neck.

  • 1 oz.
  • Paraben-free
  • Made in the USA
  • Item #66878
  • Core Product ID 333336G4RD

Ingredients

Water (Aqua), Propanediol, Leuconostoc/Radish Root Ferment Filtrate (Raphanus Sativus Root Extract) (Peptide Preservative), Lactobacillus Ferment (Peptide Preservative), Populus Tremuloides Bark Extract, Trimethylpentaediol/Adipic Acid Copolymer, Glycerin, Maltodextrin, Echinacea Angustifolia Cell Culture Extract (Hydration Stem Cell), Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine (Volumizing Peptide), Palmitoyl Dipeptide-5 Diaminohydroxybutryate (Volumizing Peptide), Centella Asiatica Meristem Cell Culture (Firming Stem Cell), Xanthan Gum, Leontopodium Alpinum Meristem Cell Culture (Smoothing Stem Cell), Gardenia Jasminoides Meristem Cell Culture (Rejuvenation Stem Cell), Buddleja Davidii Meristem Cell Culture (Antioxidant Stem Cell), Silybum Marianum Ethyl Ester, Dimethyl Isosorbide, Syringa Vulgaris (Lilac) Leaf Cell Culture Extract (Clearing Stem Cell), Pentapeptide-34 Trifluoroacetate (CQ10 Activating Peptide), Sodium Hyaluronate, Panthenol, Niacinamide, Allantoin, Magnesium Ascorbyl Phosphate, Caprylic/Capric Triglyceride, Camellia Oleifera (Green Tea) Leaf Extract, Cucumis Sativius (Cucumber) Fruit Extract, Citrus Limon (Lemon) Peel Extract, Citrus Aurantium Dulcis (Orange) Fruit Extract, Gardenia Tahitensis Flower Extract, Citrus Aurantium Dulcis (Orange) Peel Extract, Glycyrrhiza Glabra (Licorice) Root Extract, Menthyl Lactate, Isohexadecane, Isododecane, Glyceryl Caprylate, Glyceryl Undecylenate, C13-15 Alkane, Limonene, Citral, Hydroxycitronellal, Linalool, Benzyl Alcohol.
Ingredients are subject to change at the manufacturer's discretion. For the most complete and up-to-date list of ingredients, refer to the product packaging

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Reviews

(40)404.7 out of 5
Write a Review

Most helpful positive review

Oct 3, 2014

2nd bottle!!

I am getting close to the end of my first bottle of this and don't want to run out; just ordered it again. First serum I have repurchased so that tells you that I am impressed. It does what it says it does; it didn't take long for my skin to look clearer and brighter. I don't have any fine lines so can't speak to that part and don't expect it to do anything with my "puppet lines" but I have been neglecting myself for awhile and my skin had gotten dull and lifeless. When I decided to spend this much money on a serum I also decided that I would stop playing around with different products & devote at least a month to just one to be able to tell if it worked or not. I am impressed with the HydroPeptide line and am using the eye cream and the face cream. I was first impressed because unlike other high end products these contain mostly peptides and the most effective ingredients are at the top. Some product say they contain peptides etc but they are list near the bottom, meaning there is very little of that ingredient in the product. I highly recommend this for anyone looking for a serum that works. Just a pea size will work. But do yourself a favor and use it both day and night for at least a week or more.
Ridley
6found this helpful

Most helpful critical review

Apr 17, 2026

Burning

Does this have tons of alcohol in it? My face starts burning after I put on??
Ddreagan
Reposted from Hydropeptide

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Cons:

Current reviews don’t mention any.
Oct 3, 2014

2nd bottle!!

I am getting close to the end of my first bottle of this and don't want to run out; just ordered it again. First serum I have repurchased so that tells you that I am impressed. It does what it says it does; it didn't take long for my skin to look clearer and brighter. I don't have any fine lines so can't speak to that part and don't expect it to do anything with my "puppet lines" but I have been neglecting myself for awhile and my skin had gotten dull and lifeless. When I decided to spend this much money on a serum I also decided that I would stop playing around with different products & devote at least a month to just one to be able to tell if it worked or not. I am impressed with the HydroPeptide line and am using the eye cream and the face cream. I was first impressed because unlike other high end products these contain mostly peptides and the most effective ingredients are at the top. Some product say they contain peptides etc but they are list near the bottom, meaning there is very little of that ingredient in the product. I highly recommend this for anyone looking for a serum that works. Just a pea size will work. But do yourself a favor and use it both day and night for at least a week or more.
Ridley
6found this helpful
Sept 20, 2026

It works!

After 30 days with HydroStem Serum, my skin looks brighter, smoother, and more plump. It's earned a permanent spot on my shelf.
Reposted from Hydropeptide
Verified purchase
RAGia
July 4, 2026

Great serum!

I have been using this serum for at least two years and I believe that it has made a difference in my complexion.
Reposted from Hydropeptide
Verified purchase
Billow Pillow
May 14, 2026

It’s the only brand I put on my face

Repairs my skin beautifully and keep it hydrated the entire day. I use twice a day with a hyaluronic acid and moisturizer. Morning and night. My skin has never felt so soft to the touch and so inviting to the gaze.
Reposted from Hydropeptide
Verified purchase
Hydrostem
Apr 17, 2026

Burning

Does this have tons of alcohol in it? My face starts burning after I put on??
Reposted from Hydropeptide
Ddreagan
Oct 27, 2025

Gorgeous results

I have been using HydroPeptide products consistently for two years and have witnessed a transformation of my skin - it’s hydrated thru out the day, looks ten years younger and is soft and smooth. After I added HydroStem Serum to my routine, I started getting comments from family and friends like, “You have amazing skin” and “Your skin looks beautiful “. I highly recommend HydroPeptide products to all women who want to look their best.
Reposted from Hydropeptide
Verified purchase
Elizabeth, Seattle
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