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Perricone MD High Potency Triple Retinol Renewal Serum, Main, color,
Perricone MD High Potency Triple Retinol Renewal Serum, Alternate, color,
Perricone MD High Potency Triple Retinol Renewal Serum, Alternate, color,
Perricone MD High Potency Triple Retinol Renewal Serum, Alternate, color,
Perricone MD High Potency Triple Retinol Renewal Serum, Alternate, color,

High Potency Triple Retinol Renewal Serum

Perricone MD

SOLD OUT

This item is no longer available. Browse our recommendations for something similar.

Details & care

What it is: A powerful serum that works day and night to visibly reduce fine lines, wrinkles and uneven texture.

What it does: This serum uses a proprietary triple-retinol blend, antioxidant powerhouse coenzyme Q10 and naturally derived beta carotene (vitamin A) to visibly diminish uneven texture and dullness for a more even, radiant complexion. The lightweight formula accelerates skin renewal with less sensitivity to deliver the look of collagen-rich, firmer skin.

Key ingredients:

- Triple Retinol Blend: a unique blend of encapsulated retinol, retinol ester and phyto-retinol that helps deliver the look of collagen-rich skin and visibly reduce fine lines and wrinkles by accelerating surface skin exfoliation and renewal

- Coenzyme Q10 (CoQ10): an antioxidant-rich enzyme that diminishes the look of discolored and wrinkled skin by neutralizing and protecting against free radical damage

- Beta-Carotene: a naturally derived form of vitamin A that visibly minimizes photoaging effects, like redness, uneven texture and dullness by visibly repairing damaged skin caused by oxidative stress. Known as provitamin A, it protects and stabilizes retinol for maximum benefits with less sensitivity

Research results:

In a clinical study of 37 women after 4 weeks:

- 76% showed significant improvement in skin elasticity

- 76% showed significant improvement in skin resiliency

In a clinical study of 37 women after 8 weeks:

- 78% showed significant improvement in the feel of rough skin texture

- 76% showed significant improvement in skin radiance

- 76% showed a significant reduction in fine lines on the cheek

- 76% showed a significant reduction in age and sun spots

In a clinical study of 38 women:

- Increases surface skin renewal in 3 days

How to use: After cleansing, massage onto face and neck using a gentle upward motion. Wait until fully absorbed and follow with your favorite Perricone MD moisturizer. Use morning and evening. If used in the morning, follow with SPF. If you are new to retinol, start by applying for 1–2 nights per week and increase gradually as tolerated.

  • 2 oz.
  • Fragrance-free
  • Item #10529062

Ingredients

Water/Aqua/Eau, Glycerin, Dimethicone, Propanediol, Squalane, Butylene Glycol, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Niacinamide, Rubus Idaeus (Raspberry) Seed Oil, Lactobacillus Ferment, Phenoxyethanol, Polyacrylate Crosspolymer-6, Pentylene Glycol, Caprylic/Capric Triglyceride, Ethylhexylglycerin, Linum Usitatissimum (Linseed) Seed Extract, Tetrasodium Glutamate Diacetate, Mannose, Sodium Mannose Phosphate, Ceramide NP, Allantoin, Aloe Barbadensis Leaf, Bisabolol, Retinol, Polysorbate 20, Lecithin, Polysorbate 60, Sorbitan Isostearate, Chlorella Vulgaris Extract, Hydrogenated Phosphatidylcholine, Lysolecithin, Retinyl Linoleate, Hydroxyphenyl Propamidobenzoic Acid, Cetyl Palmitate, Laureth-23, Sodium Hyaluronate Crosspolymer, Tocopheryl Acetate, Glyceryl Caprylate, P-Anisic Acid, Glycine Soja (Soybean) Oil, Sodium Hydroxide, Sodium Hyaluronate, Thioctic Acid, Trideceth-6 Phosphate, Sodium Acetylated Hyaluronate, Ubiquinone, Tocopherol, Citric Acid, Hyaluronic Acid, Hydrolyzed Glycosaminoglycans, Hydrolyzed Sodium Hyaluronate, 1,2-Hexanediol, Lactic Acid, Sodium Benzoate, Ascorbyl Palmitate, Potassium Sorbate, Hydrolyzed Hyaluronic Acid, Beta-Carotene, Daucus Carota Sativa (Carrot) Root Extract, Phytic Acid, Caprylhydroxamic Acid, Beta-Sitosterol, Squalene, Arginine/Lysine Polypeptide.
Ingredients are subject to change at the manufacturer's discretion. For the most complete and up-to-date list of ingredients, refer to the product packaging

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Perricone MD

Perricone MD founder Dr. Nicholas Perricone believes that true beauty comes from incredibly radiant health. The company's products use the most powerful ingredients on the planet, and are rooted in a holistic approach that is backed by science and research. Perricone MD never compromises on excellence and innovation because it's on a mission to revolutionize skin care for results you can see.

Reviews

(964)
4.8 out of 5
Write a Review

Most helpful positive review

Apr 21, 2026
Best retinol ever
The best retinol product I’ve ever used. My insurance covers a prescription retinol (it’s been underwhelming), so I was hesitant to start buying this Triple Retinol Serum as it’s on the pricey side. After trying the samples I got with another purchase, though, the improvement was pretty noticeable. I finally gave in and purchased it and I’m so happy with the results. I use it nightly and it seems pretty gentle, though I don’t have sensitive skin so take that with a grain of salt. Highly recommend this product.
En
Verified purchase
Reposted from Perricone MD
Perricone MD response
Thank you for your fantastic review! It’s wonderful to hear that you enjoyed "High Potency Triple Retinol Renewal Serum" Don’t hesitate to share your thoughts any time!

Most helpful critical review

Nov 22, 2025
Not good at all
I expected a better product from Perricone. I am very dissatisfied with this product. The moisturizer cream is a terrible cream; does nothing for your face. Bye Perricone!!!
Yes.
Verified purchase
Reposted from Perricone MD
Perricone MD response
Thank you so much for taking the time to share your experience with us. We regret that the High Potency Triple Retinol Renewal Serum did not meet your expectations. Your feedback helps us improve, and we will be sure to pass this along to the relevant team.
5 stars
81%
4 stars
17%
3 stars
1%
2 stars
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Sort by Most Helpful
En
Reposted from Perricone MD
Verified purchase
Apr 21, 2026
Best retinol ever
The best retinol product I’ve ever used. My insurance covers a prescription retinol (it’s been underwhelming), so I was hesitant to start buying this Triple Retinol Serum as it’s on the pricey side. After trying the samples I got with another purchase, though, the improvement was pretty noticeable. I finally gave in and purchased it and I’m so happy with the results. I use it nightly and it seems pretty gentle, though I don’t have sensitive skin so take that with a grain of salt. Highly recommend this product.
Perricone MD response
Thank you for your fantastic review! It’s wonderful to hear that you enjoyed "High Potency Triple Retinol Renewal Serum" Don’t hesitate to share your thoughts any time!
Karen D
Reposted from Perricone MD
Verified purchase
Apr 16, 2026
Impressive duo
[This review was collected as part of a promotion.] First time using these retinol products and am a long-time Perricone customer. I've been using these about 6 weeks and like the products - not greasy and quickly absorbed. Don't yet see visible results but will update in another 3 months.
Teresa
Reposted from Perricone MD
Verified purchase
Apr 14, 2026
The sample sold me on the product
I received samples to try and the results were noticeable. I ordered it and will be using it next.
Perricone MD response
Thank you so much for your kind words!
Austin
Reposted from Perricone MD
Verified purchase
Apr 14, 2026
Effective Serum
I’ve been really impressed with Perricone’s Triple Retinol Serum. It feels like a well-made product, and you can tell the quality is there. After using it consistently, I noticed my skin looked smoother and more refined overall. It’s effective without feeling harsh, which I really appreciated. Definitely one of those products that feels worth using if you want real results from a retinol serum.
Perricone MD response
Thank you for sharing such a detailed review! It’s great to know the formula feels effective yet gentle, balancing results with comfort is exactly what we aim for. We truly appreciate your thoughtful feedback and support!
SB
Reposted from Perricone MD
Verified purchase
Apr 8, 2026
Perricone’s Serum is Best
Both serums are effective and a must for the ski .
Perricone MD response
Thank you for your review! We're so glad both serums are helping keep your skin healthy and glowing.
Sharireader
Reposted from Perricone MD
Verified purchase
Mar 2, 2026
Great Product!
I'm liking the changes to my skin since I started using this retinol product. Unfortunately, though, the eye treatment makes my eyes water,
Perricone MD response
We love your insights. Keep them coming!
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