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(969)969

High Potency Triple Retinol Renewal Serum

Perricone MD

Sold Out

SOLD OUT

This item is no longer available. Browse our recommendations for something similar.

Details & care

What it is: A powerful serum that works day and night to visibly reduce fine lines, wrinkles and uneven texture.

What it does: This serum uses a proprietary triple-retinol blend, antioxidant powerhouse coenzyme Q10 and naturally derived beta carotene (vitamin A) to visibly diminish uneven texture and dullness for a more even, radiant complexion. The lightweight formula accelerates skin renewal with less sensitivity to deliver the look of collagen-rich, firmer skin.

Key ingredients:
- Triple Retinol Blend: a unique blend of encapsulated retinol, retinol ester and phyto-retinol that helps deliver the look of collagen-rich skin and visibly reduce fine lines and wrinkles by accelerating surface skin exfoliation and renewal
- Coenzyme Q10 (CoQ10): an antioxidant-rich enzyme that diminishes the look of discolored and wrinkled skin by neutralizing and protecting against free radical damage
- Beta-Carotene: a naturally derived form of vitamin A that visibly minimizes photoaging effects, like redness, uneven texture and dullness by visibly repairing damaged skin caused by oxidative stress. Known as provitamin A, it protects and stabilizes retinol for maximum benefits with less sensitivity

Research results:
In a clinical study of 37 women after 4 weeks:
- 76% showed significant improvement in skin elasticity
- 76% showed significant improvement in skin resiliency
In a clinical study of 37 women after 8 weeks:
- 78% showed significant improvement in the feel of rough skin texture
- 76% showed significant improvement in skin radiance
- 76% showed a significant reduction in fine lines on the cheek
- 76% showed a significant reduction in age and sun spots
In a clinical study of 38 women:
- Increases surface skin renewal in 3 days

How to use: After cleansing, massage onto face and neck using a gentle upward motion. Wait until fully absorbed and follow with your favorite Perricone MD moisturizer. Use morning and evening. If used in the morning, follow with SPF. If you are new to retinol, start by applying for 1–2 nights per week and increase gradually as tolerated.

  • 2 oz.
  • Fragrance-free
  • Item #10529062
  • Core Product ID 333333K2LV

Ingredients

Water/Aqua/Eau, Glycerin, Dimethicone, Propanediol, Squalane, Butylene Glycol, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Niacinamide, Rubus Idaeus (Raspberry) Seed Oil, Lactobacillus Ferment, Phenoxyethanol, Polyacrylate Crosspolymer-6, Pentylene Glycol, Caprylic/Capric Triglyceride, Ethylhexylglycerin, Linum Usitatissimum (Linseed) Seed Extract, Tetrasodium Glutamate Diacetate, Mannose, Sodium Mannose Phosphate, Ceramide NP, Allantoin, Aloe Barbadensis Leaf, Bisabolol, Retinol, Polysorbate 20, Lecithin, Polysorbate 60, Sorbitan Isostearate, Chlorella Vulgaris Extract, Hydrogenated Phosphatidylcholine, Lysolecithin, Retinyl Linoleate, Hydroxyphenyl Propamidobenzoic Acid, Cetyl Palmitate, Laureth-23, Sodium Hyaluronate Crosspolymer, Tocopheryl Acetate, Glyceryl Caprylate, P-Anisic Acid, Glycine Soja (Soybean) Oil, Sodium Hydroxide, Sodium Hyaluronate, Thioctic Acid, Trideceth-6 Phosphate, Sodium Acetylated Hyaluronate, Ubiquinone, Tocopherol, Citric Acid, Hyaluronic Acid, Hydrolyzed Glycosaminoglycans, Hydrolyzed Sodium Hyaluronate, 1,2-Hexanediol, Lactic Acid, Sodium Benzoate, Ascorbyl Palmitate, Potassium Sorbate, Hydrolyzed Hyaluronic Acid, Beta-Carotene, Daucus Carota Sativa (Carrot) Root Extract, Phytic Acid, Caprylhydroxamic Acid, Beta-Sitosterol, Squalene, Arginine/Lysine Polypeptide.
Ingredients are subject to change at the manufacturer's discretion. For the most complete and up-to-date list of ingredients, refer to the product packaging

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Perricone MD

Perricone MD founder Dr. Nicholas Perricone believes that true beauty comes from incredibly radiant health. The company's products use the most powerful ingredients on the planet, and are rooted in a holistic approach that is backed by science and research. Perricone MD never compromises on excellence and innovation because it's on a mission to revolutionize skin care for results you can see.

Reviews

(969)9694.8 out of 5
Write a Review

Most helpful positive review

June 30, 2026

Silky glow cream.

I used this at night and the next morning my skin is just so shiny and beautiful and soft. I love it.
Barbara
Verified purchase

Most helpful critical review

Nov 22, 2025

Not good at all

I expected a better product from Perricone. I am very dissatisfied with this product. The moisturizer cream is a terrible cream; does nothing for your face. Bye Perricone!!!
Yes.
Verified purchase

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5 stars81%
4 stars17%
3 stars1%
2 stars1%
1 star0%
Sept 2, 2026

Be careful how often a week you use this

I can only use this once a week otherwise i get red blotches on my skin
Verified purchase
Alfredo
June 30, 2026

Silky glow cream.

I used this at night and the next morning my skin is just so shiny and beautiful and soft. I love it.
Verified purchase
Barbara
June 23, 2026

Reduced wrinkles

Fine line improvement with just a few applications
Verified purchase
Lmc
May 28, 2026

My favorite skin care product!

I started using this product about 3 weeks ago and in that short amount of time I have noticed an incredible difference in my skin. My pores are noticeably smaller, acne has subsided, dark marks fading, and fine lines are smoother. I have gotten so many compliments on my glowing skin. I also find it doesn’t leave my skin irritated, red, and flakey like some other retinol. I never write reviews but I am so happy with how this product makes me look and feel 10/10 recommend!
Anonymous
May 19, 2026

Excellent products

[This review was collected as part of a promotion.] They are both great products. Im enjoying the results. My skin looks more radiant. Im more confident wearing less make up.
Verified purchase
Dwidrick
May 19, 2026

Excellent product good value

Excellent product not greasy use daily skin improvement
Verified purchase
Rose A
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