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Clear Comeback Probiotic Enzyme Powder Refill video
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Clear Comeback Probiotic Enzyme Powder Refill

Exponent Beauty

Current Price $68.00
One Size
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Get $40 off your next purchase! When you're approved for a new Nordstrom credit card. Plus, an extra 5% off at Nordstrom Rack. Terms apply. Apply Now

Highlights

  • Hyaluronic acid
  • Good for: Acne & blemishes
  • Good for: Oily skin & large pores

Details & care

What it is: A blemish-busting, pore-refining clinical-grade powder serum refill designed for use with Exponent’s refillable two-part Powder Serum Powder Dispenser (sold separately). Powered by enzymes, probiotics, willow bark (natural salicylic acid) and multiweight hyaluronic acid, this formula stays in its most potent powder form until activated fresh for peak efficacy. Clinically tested, it is proven to improve breakouts, blackheads, enlarged pores, fine lines and wrinkles, while balancing the microbiome and supporting the skin barrier.

Who it's for: Ideal for all skin types, including acne-, blemish- and breakout-prone skin, as well as dry, mature or clogged skin. Perfect for those seeking to refine pores, reduce blackheads, smooth texture and support anti-aging benefits. Not safe for pregnant or nursing mothers.

What it does: This clarifying, smoothing and anti-aging powder serum visibly reduces blemishes, blackheads and breakouts while minimizing the appearance of pores. It helps smooth skin texture and reduce dullness for a more even, radiant glow.
The powder serum supports a healthy microbiome and repairs the skin barrier for resilient, balanced skin. It deeply hydrates to plump dry skin, while helping reduce the appearance of fine lines and wrinkles. Powered by salicylic acid (willow bark) to gently exfoliate, control oil and combat acne-causing bacteria.

Key ingredients:
- Willow bark (salicylic acid): natural exfoliant and acne-fighter that may reduce blemishes, blackheads, breakouts and controls excess oil.
- Enzymes (bromelain and papain): gently exfoliate, smooth texture and reduce dullness.
- Probiotics (lactobacillus): supports microbiome balance and strengthens the skin barrier for healthier, resilient skin
- Hyaluronic acid: multiweight HA delivers deep hydration to plump dry skin and leave it smoother and radiant

Research results:
Based on clinical testing study with measured instrumentation of 32 subjects evaluated with a Visia Image Analysis Pro over 6 weeks:
- 100% of subjects had a decrease in papules (blemishes/pimples) in 1 week
- 94% of subjects had a decrease in visible pore size in 1 week
- 63% of subjects had an improvement in skin texture/smoothness after 1 week

How to use: The powder refill should be used in Exponent's Refillable Power Serum Powder Dispenser as a refill for a previously purchased Power Serum.
1. Stamp Active Powder in Palm for one precise dose (this keeps anti-aging ingredients at peak potency).
2. Pump one dose of hyaluronic acid; mix in palm (this activates powders into hydrating, silky serums)
3. Apply serum to face and neck
Clear Comeback can be used as the first layer on clean skin, morning and evening. Layer underneath a moisturizer or SPF.

  • Clear Comeback Probiotic Enzyme Powder Refill only; designed to be combined with Exponent’s Hyaluronic Acid Serum (sold separately)
  • Paraben-free; phthalate-free; sulfate-free; fragrance-free; silicone-free
  • Made in the USA
  • Item #11081775
  • Core Product ID 33333454GR

Shipping & returns

Free shipping. Free returns. All the time. Purchases made online can also be returned or exchanged at any Nordstrom store, free of charge. Read more about our shipping & returns policies.

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Exponent Beauty

Exponent Beauty

Reviews

(88)884.5 out of 5
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Most helpful positive review

June 27, 2026

Probiotic Enzyme Power Serum and Vitamin C Serum

I was having a terrible time with breakouts and developing some brown spots. I was getting no where with my dermatologist so I bought both of these treatment serums. In a week there was a visible change in my skin and two weekends out, I have no breakouts. Everything is healing and the redness is almost gone. I use the Enzyme in the AM and sleep with the Vitamin C. The Vitamain C is the best since it addresses the breakouts and it’s starting to look like the spots are lightening. What I like best about both serums is that their effectiveness isn’t subject to oxidation, since they mix just before using them. Vitmain C is notorious for becoming oxidized and useless, but that can’t happen with this Vitamin C since it is a stable powder duntil you mix it to use it. Love it!
Anita S.

Most helpful critical review

Jan 26, 2025

Poorly designed product

Despite following instructions of keeping the lid over container to keep it dry, product congealed and became unusable after 3 weeks. For such a pricey product, it was enough for me to cancel all my subscriptions.
Christina L.

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5 stars73%
4 stars15%
3 stars8%
2 stars3%
1 star1%
June 27, 2026

Probiotic Enzyme Power Serum and Vitamin C Serum

I was having a terrible time with breakouts and developing some brown spots. I was getting no where with my dermatologist so I bought both of these treatment serums. In a week there was a visible change in my skin and two weekends out, I have no breakouts. Everything is healing and the redness is almost gone. I use the Enzyme in the AM and sleep with the Vitamin C. The Vitamain C is the best since it addresses the breakouts and it’s starting to look like the spots are lightening. What I like best about both serums is that their effectiveness isn’t subject to oxidation, since they mix just before using them. Vitmain C is notorious for becoming oxidized and useless, but that can’t happen with this Vitamin C since it is a stable powder duntil you mix it to use it. Love it!
Anita S.
Apr 13, 2026

A results driven serum

I’ve been using the Clear Comeback Probiotic Enzyme Power Serum consistently for a few weeks now. Right before I started using it my skin was definitely in a rough patch. I had quite a few breakouts, my skin was dehydrated and felt more red/inflamed than usual. My skin type is combination, and is somewhat breakout prone, with rosacea on my cheeks.I’ve been working in skincare and beauty for almost 20 years and I have tried a lot of serums with willow bark and probiotics, but I feel like what Exponent is doing is different. I was excited to try their system.So far I love this serum. It has really helped to calm down my skin, and treat the breakouts I was having. It also treated the dehydration I was experiencing! My skin overall looks clearer, feels more hydrated and balanced. The pores and on my nose do look a bit more refined as well.I have more significant/deeper orange peel skin in the creases of my nose. I haven’t seen a noticeable change in that but I know that is something that would potentially take longer to see results. It has helped to reduce the whiteheads I get there generally though which is great.The only cons I would say are that for me personally one pump doesn’t feel like it dispenses quite enough product. I feel like I need to pump two if I want to really comfortably cover my face especially if I want to pull it down to my neck. And the other con is that my hands are really sticky after I use it this isn’t one I can rub in the excess on my hands and leave it on. Definitely feel like I have to rinse my hands after but that’s not a big deal.Overall I think the concept of dispensing the powder and serum with each use to maintain potency is really cool and I would absolutely call this a results driven product. I would repurchase and recommend. *This review was collected as part of a promotion.
marjoriejune
Apr 13, 2026

Amazing Power

Exponent clear comeback probiotic enzyme worked for me. I noticed after the first couple days a difference in skin texture, it was smoother, my pores getting smaller, my face finally felt hydrated. The serum is amazing a gel-like feel with no stickiness, but leaves your face feeling refreshing and hydrated. I put this on in the morning for my first layer then I apply a moisturizer. The process is not time consuming at at just stamp powder in palm for one precise dose and then pump one dose of the hyaluronic acid, the mix in palm and then apply. It did not irritate my skin. I’m a witness and can say within one week I noticed decrease in blemishes/pimples, decrease in visible pore size, and also it has improved my texture of my skin and its smooth. This is a game changer, its a little pricey but it is worth it. I received this product in exchange for my honest review. *This review was collected as part of a promotion.
keshia05
Apr 12, 2026

Very impressed!

I initially was intrigued by the concept of this Exponent Clear Comeback Probiotic Enzyme Power Serum, mixing the powder with the liquid for the most potency of ingredients. It turned about to akso be kind of fun, mixing my own skin care! The formula absorbs into skin well, is not sticky or greasy, does not irritate my skin, and works well under my makeup. After using this for a few weeks, I have not had a single breakout during that time and my pores are less noticeable. I’m very impressed with the results. *This review was collected as part of a promotion.
mandy325
Apr 12, 2026

Futuristic Skincare!

Using this Exponent Activated serum felt like something almost futuristic. I’ve never used a skincare product that activates in real time so I was really excited to try this. For starters I do have to say the bottle mechanics for the powder took me a minute to figure out. But once I did, I was very impressed with how easy and precise the amount was. No worrying about waste! The hydrator was ready to go so no struggles there, I do wonder if I used more than I should have. The consistency ends up thin and gel like when mixed and smells so good when first activated. After a week of using, I do notice that my skin overall feels softer and smoother. I also struggle with larger pores and blackheads and see an improvement in both. I loved using this product and I’m an Exponent fan now for sure! *This review was collected as part of a promotion.
raereviewsstuff
Apr 11, 2026

Slowly melting the blackheads away!

The Exponent Beauty Clear Comeback Probiotic Enzyme Power Serum has been such a game changer for me. Naturally, I have very large pores that get congested despite regular skin care. I have a concert are full of different serums that I rotate through with hopes that my poor would shrink or at least not be black. I use a lot of sunscreen and that’s typically when the blackheads become an ongoing challenge. The Exponent Beauty Clear Comeback Probiotic Enzyme Power Serum has done a pretty good job in reducing the amount of blackheads that I have. It didn’t totally eliminate the blackouts but overall, I noticed that with consistent use the size of the blackheads have been smaller. Initially I was using xxx twice daily, but didn’t care for how it layered with my makeup. I switched to using it once a day and I’m quite impressed because it’s a preventative product. It has been an amazing job of keeping my pores smaller. I didn’t expect the Exponent Beauty Clear Comeback Probiotic Enzyme Power Serum to eliminate all the blackheads, but the fact that there are fewer visible blackheads on my nose makes me very happy. The texture of the product is very hydrating. First off let’s just say the packaging is amazing. When you open it, you feel like you’re transported to the future. I did have a hard time opening the product, but once I figure it out, it was very enjoyable to use. Didn’t experience any skin irritation or breakouts. Overall, such a great product as it minimize the size of the blackheads and didn’t break me out. Overall, I would recommend it for any one who struggles with blackheads. My son has been using it and honestly, his nose feels so smooth. I think the biggest barrier is probably the cost a tad pricey but definitely worth it. This product was provided for promotional purposes in exchange for my honest review.
Nachod