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Details & care
What it is: A nightly serum that helps restore skin's youthful bounce and glow for those showing moderate to visible aging signs.
What it does: Advanced Leontopod Stem Cell technology helps organically identify and repair damage deep within the skin; ECM Moduline Peptide stimulates collagen response while you sleep so you awake to firmer, smoother-looking skin; and volumizing cross-linked HA filling spheres drawn from skin's deepest moisture source fill and plump the appearance of fine lines and wrinkles. This serum also contains an evening time-release retinol compound to help repair mechanical wrinkling damage. Its airless jar keeps the active ingredients at peak concentration.
How to use: Use at night. Massage 1–2 pumps of serum onto your entire face. It's recommended for use immediately after cleansing skin.
- 1 oz.
- Natural Beauty & Wellness products are free of sulfates, phthalates, parabens, petrochemicals, mineral oil, silicone and talc
- Cruelty-free
- Made in the USA
- Item #5501998
Ingredients
Water (Aqua),Ethylhexyl Palmitate, Glycerin, Peg-40 Hydrogenated Castor Oil, Caprylic/Capric Triglyceride, Sodium Hyaluronate, Bisabolol, Leontopodium Alpinum Meristem Cell Culture, Dimethyl Isosorbide, Panthenol, Tetrahexyldecyl Ascorbate, Amorphophallus Konjac Root Powder, Leuconostoc/Radish Root Ferment Filtrate, Commiphora Mukul Resin Extract, Tocopherol, Allantoin, Hydroxypinacolone Retinoate, Palmitoyl Tripeptide-28, Disodium Edta, Carbomer, Trihydroxystearin, Aminomethyl Propanol, Phenoxyethanol, Xanthan Gum, Silica, Chlorphenesin, Benzoic Acid, Butylene Glycol, Sorbic Acid, Mica, Titanium Dioxide.
Ingredients are subject to change at the manufacturer's discretion. For the most complete and up-to-date list of ingredients, refer to the product packaging
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BeautyBio
Cofounded by Jamie O'Banion, BeautyBio is a line of results-driven, clean, performance skin care with the GloPRO® at its core. This microneedling facial tool is a patented, award-winning tool that helps visibly restore volume and deliver a firmer, smoother and younger-looking appearance. Paired with their carefully designed proprietary topicals, BeautyBio puts the power of in-office results in the palm of your hand.
Most helpful positive review
May 10, 2019
Simply amazing!
I have become a Beautybio girl. The whole line is simply and amazing! I used the r45 and now my maintenance is the nightly. Never irritated my skin and has a light smell. Great line!
jonijoy
6found this helpful
Most helpful critical review
Oct 25, 2018
I did not like this skincare line at all
I am not happy with this skincare line at all! I spent over $500 on the products recommended for my skin type. I did everything exactly as the product instructions indicated. And I have given the products one month to have a fair opinion. Not only did these products not help my skin in ANY way, but it made my skin worse! I have never broken out the way that I did while using these products, it was terrible! And I have not noticed any beneficial changes in my skin at all. The step 1 wash cleanses my skin well and I like the smell, but every other product, including this Nightly Serum, was very disappointing. I wanted to love it, but I did not.
Jaime V.
Reposted from beautybio.com
5 stars
82%
4 stars
11%
3 stars
4%
2 stars
2%
1 star
1%
Sort by Most Helpful
jonijoy
May 10, 2019
Simply amazing!
I have become a Beautybio girl. The whole line is simply and amazing! I used the r45 and now my maintenance is the nightly. Never irritated my skin and has a light smell. Great line!
6found this helpful
Katherine69
July 5, 2018
Incentivized review
Results Worth Waiting For!
Always searching for just the right treatment for my aging skin, The Nightly caught my attention as soon as I heard about it from a friend in the same situation. Two phrases stood out: time-release retinol and Leontopod stem-cell technology. After using as a companion with my GloPRO every night for a week, I didn't have to ask myself if it were working, I could feel the difference. Softer and smoother, then clearer and more toned from the inside out, my skin feels released from the ravages of time. I call THAT time release!
6found this helpful
Trixxi
Verified purchase
June 26, 2018
Incentivized review
Beauty Bioscience Peptide Serum: Smooth as Silk
Instant love for this high performance unscented white gel serum that goes on smooth, absorbs well, results in soft, silky skin, reduced lines and wrinkles. My sensitive skin responds well to peptides and retinol, and this delivers overnight results. The hygienic airtight bottle is good.
3found this helpful
CFrench
May 22, 2018
Incentivized review
Nightly Skincare Necessity
This is easily one of the best products I've added to my nightly skincare routine! When I wake up in the morning, my skin looks and feels noticeably soft and hydrated.
2found this helpful
Tori T.
Reposted from beautybio.com
Jan 12, 2026
Love This ❤️
I really love that it doesn't burn! I wake up looking dewy & refreshed! That's the way with all Beautybio
LP
Reposted from beautybio.com
Dec 25, 2025
The best retinol I've ever tried!
I was using a different retinol for the longest time without seeing any results. Decided to give Beauty Bio's one a chance and boy did it deliver!
So yourself a favor and get The Nightly, you won't regret it!
