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Perricone MD High Potency Triple Retinol Renewal Serum, Main, color,
Perricone MD High Potency Triple Retinol Renewal Serum, Alternate, color,
Perricone MD High Potency Triple Retinol Renewal Serum, Alternate, color,
Perricone MD High Potency Triple Retinol Renewal Serum, Alternate, color,
Perricone MD High Potency Triple Retinol Renewal Serum, Alternate, color,

High Potency Triple Retinol Renewal Serum

Perricone MD

SOLD OUT

This item is no longer available. Browse our recommendations for something similar.

Details & care

What it is: A powerful serum that works day and night to visibly reduce fine lines, wrinkles and uneven texture.

What it does: This serum uses a proprietary triple-retinol blend, antioxidant powerhouse coenzyme Q10 and naturally derived beta carotene (vitamin A) to visibly diminish uneven texture and dullness for a more even, radiant complexion. The lightweight formula accelerates skin renewal with less sensitivity to deliver the look of collagen-rich, firmer skin.

Key ingredients:

- Triple Retinol Blend: a unique blend of encapsulated retinol, retinol ester and phyto-retinol that helps deliver the look of collagen-rich skin and visibly reduce fine lines and wrinkles by accelerating surface skin exfoliation and renewal

- Coenzyme Q10 (CoQ10): an antioxidant-rich enzyme that diminishes the look of discolored and wrinkled skin by neutralizing and protecting against free radical damage

- Beta-Carotene: a naturally derived form of vitamin A that visibly minimizes photoaging effects, like redness, uneven texture and dullness by visibly repairing damaged skin caused by oxidative stress. Known as provitamin A, it protects and stabilizes retinol for maximum benefits with less sensitivity

Research results:

In a clinical study of 37 women after 4 weeks:

- 76% showed significant improvement in skin elasticity

- 76% showed significant improvement in skin resiliency

In a clinical study of 37 women after 8 weeks:

- 78% showed significant improvement in the feel of rough skin texture

- 76% showed significant improvement in skin radiance

- 76% showed a significant reduction in fine lines on the cheek

- 76% showed a significant reduction in age and sun spots

In a clinical study of 38 women:

- Increases surface skin renewal in 3 days

How to use: After cleansing, massage onto face and neck using a gentle upward motion. Wait until fully absorbed and follow with your favorite Perricone MD moisturizer. Use morning and evening. If used in the morning, follow with SPF. If you are new to retinol, start by applying for 1–2 nights per week and increase gradually as tolerated.

  • 2 oz.
  • Fragrance-free
  • Item #10529062

Ingredients

Water/Aqua/Eau, Glycerin, Dimethicone, Propanediol, Squalane, Butylene Glycol, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Niacinamide, Rubus Idaeus (Raspberry) Seed Oil, Lactobacillus Ferment, Phenoxyethanol, Polyacrylate Crosspolymer-6, Pentylene Glycol, Caprylic/Capric Triglyceride, Ethylhexylglycerin, Linum Usitatissimum (Linseed) Seed Extract, Tetrasodium Glutamate Diacetate, Mannose, Sodium Mannose Phosphate, Ceramide NP, Allantoin, Aloe Barbadensis Leaf, Bisabolol, Retinol, Polysorbate 20, Lecithin, Polysorbate 60, Sorbitan Isostearate, Chlorella Vulgaris Extract, Hydrogenated Phosphatidylcholine, Lysolecithin, Retinyl Linoleate, Hydroxyphenyl Propamidobenzoic Acid, Cetyl Palmitate, Laureth-23, Sodium Hyaluronate Crosspolymer, Tocopheryl Acetate, Glyceryl Caprylate, P-Anisic Acid, Glycine Soja (Soybean) Oil, Sodium Hydroxide, Sodium Hyaluronate, Thioctic Acid, Trideceth-6 Phosphate, Sodium Acetylated Hyaluronate, Ubiquinone, Tocopherol, Citric Acid, Hyaluronic Acid, Hydrolyzed Glycosaminoglycans, Hydrolyzed Sodium Hyaluronate, 1,2-Hexanediol, Lactic Acid, Sodium Benzoate, Ascorbyl Palmitate, Potassium Sorbate, Hydrolyzed Hyaluronic Acid, Beta-Carotene, Daucus Carota Sativa (Carrot) Root Extract, Phytic Acid, Caprylhydroxamic Acid, Beta-Sitosterol, Squalene, Arginine/Lysine Polypeptide.
Ingredients are subject to change at the manufacturer's discretion. For the most complete and up-to-date list of ingredients, refer to the product packaging

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Perricone MD

Perricone MD founder Dr. Nicholas Perricone believes that true beauty comes from incredibly radiant health. The company's products use the most powerful ingredients on the planet, and are rooted in a holistic approach that is backed by science and research. Perricone MD never compromises on excellence and innovation because it's on a mission to revolutionize skin care for results you can see.

Reviews

(959)
4.8 out of 5
Write a Review

Most helpful positive review

Mar 2, 2026
Great Product!
I'm liking the changes to my skin since I started using this retinol product. Unfortunately, though, the eye treatment makes my eyes water,
Sharireader
Verified purchase
Reposted from Perricone MD
Perricone MD response
We love your insights. Keep them coming!

Most helpful critical review

Nov 22, 2025
Not good at all
I expected a better product from Perricone. I am very dissatisfied with this product. The moisturizer cream is a terrible cream; does nothing for your face. Bye Perricone!!!
Yes.
Verified purchase
Reposted from Perricone MD
Perricone MD response
Thank you so much for taking the time to share your experience with us. We regret that the High Potency Triple Retinol Renewal Serum did not meet your expectations. Your feedback helps us improve, and we will be sure to pass this along to the relevant team.
5 stars
81%
4 stars
17%
3 stars
1%
2 stars
1%
1 star
0%
Sort by Most Helpful
Sharireader
Reposted from Perricone MD
Verified purchase
Mar 2, 2026
Great Product!
I'm liking the changes to my skin since I started using this retinol product. Unfortunately, though, the eye treatment makes my eyes water,
Perricone MD response
We love your insights. Keep them coming!
Svitlana
Reposted from Perricone MD
Verified purchase
Jan 6, 2026
Good
very high quality brand, I have been using it for 5 years. everything is great
Perricone MD response
Your feedback helps us grow. Share more!
Linda
Reposted from Perricone MD
Verified purchase
Dec 31, 2025
Good.
Maintaining my skin. Use on face and neck. Just maintaining. No spectacular results.
Perricone MD response
Thank you so much for your honest feedback! We’re happy to hear that you are liking the High Potency Triple Retinol Renewal Serum. We’re excited for you to keep using it and see more results.
Rita
Reposted from Perricone MD
Verified purchase
Dec 25, 2025
Triple Retinol Renewal Serum
No scent, which I like. The serum is light in consistency. The size is portable for travel. A rating of 4 due to the stinging when applied.
Perricone MD response
Thank you for sharing your feedback with us. We truly appreciate you taking the time to let us know your thoughts, and we will be sure to pass this along to the relevant team.
EllenMM
Reposted from Perricone MD
Verified purchase
Dec 18, 2025
Amazing results that don’t hurt my skin
Phenomenal and gentle results show within days. One of the things I love about this brand is that every product is immediately absorbed into my skin. No more waiting to start my makeup and the moisture lasts all day.
Yes.
Reposted from Perricone MD
Verified purchase
Nov 22, 2025
Not good at all
I expected a better product from Perricone. I am very dissatisfied with this product. The moisturizer cream is a terrible cream; does nothing for your face. Bye Perricone!!!
Perricone MD response
Thank you so much for taking the time to share your experience with us. We regret that the High Potency Triple Retinol Renewal Serum did not meet your expectations. Your feedback helps us improve, and we will be sure to pass this along to the relevant team.
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